公开(公告)号：WO2012072715A2

公开(公告)日：2012-06-07

申请号：PCT/EP2011071446

申请日：2011-11-30

Applicant: UNIV ZUERICH ,  UNIV BERN ,  ZANGEMEISTER-WITTKE UWE ,  HUWILER ANDREA ,  GRUETTER MARKUS G ,  BOURQUIN FLORENCE

Inventor： ZANGEMEISTER-WITTKE UWE ,  HUWILER ANDREA ,  GRUETTER MARKUS G ,  BOURQUIN FLORENCE

CPC classification number: A61K38/51 ,  A61K31/7088

Abstract: The present invention relates to the use of prokaryotic sphingosine-1 -phosphate lyases (S1PL) and S1PLs that lack a transmembrane domain or of a nucleic acid encoding such an S1PL in the prevention or treatment of a disease condition associated with elevated levels of sphingosine-1 -phosphate (S1P), and for which S1P elevation is directly or indirectly causative. In addition, the invention relates to a new product in the form of S1PL lacking the N-terminal loop domain.

Abstract translation: 本发明涉及原核鞘氨醇-1-磷酸裂合酶（S1PL）和缺乏跨膜结构域的S1PL或编码这种S1PL的核酸在预防或治疗与鞘氨醇 - 1-磷酸（S1P），并且其S1P升高直接或间接成为原因。 此外，本发明涉及S1PL形式的缺乏N端环域的新产物。