A method and apparatus are described for minimizing inter-cell interference at multiple wireless transmit/receive units (WTRUs) using a shared node (SN). Each WTRU may be configured to receive a desired signal transmitted by a base station in a cell combined with interfering signals transmitted by other base stations in other cells in a first transmission time interval (TTI), and a precoded signal transmitted by the SN in a second TTI. The WTRUs may buffer the desired and interfering mixed signals received in the first TTI, and then combine the buffered signals with the precoded signal received in the second TTI to minimize the interfering signal's power and maximize the desired signal's power at each WTRU so that the desired signal may be decoded with higher probability. The SN may generate the precoded signal based on codewords or codeword components transmitted by the base stations in the same resource blocks.