发明申请
WO2012097177A2 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
审中-公开
取代的苯并吖庚因作为TOLL样受体调节剂
- 专利标题： SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
- 专利标题（中）： 取代的苯并吖庚因作为TOLL样受体调节剂
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申请号： PCT/US2012/021116申请日： 2012-01-12
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公开(公告)号： WO2012097177A2公开(公告)日： 2012-07-19
- 发明人: HOWBERT, James, Jeffry , HERSHBERG, Robert
- 申请人： VENTIRX PHARMACEUTICALS, INC. , ARRAY BIOPHARMA, INC. , HOWBERT, James, Jeffry , HERSHBERG, Robert
- 申请人地址： 1700 Seventh Avenue, Suite 1900 Seattle, WA 98101-1397 US
- 专利权人： VENTIRX PHARMACEUTICALS, INC.,ARRAY BIOPHARMA, INC.,HOWBERT, James, Jeffry,HERSHBERG, Robert
- 当前专利权人： VENTIRX PHARMACEUTICALS, INC.,ARRAY BIOPHARMA, INC.,HOWBERT, James, Jeffry,HERSHBERG, Robert
- 当前专利权人地址： 1700 Seventh Avenue, Suite 1900 Seattle, WA 98101-1397 US
- 代理机构： ELRIFI, Ivor, R. et al.
- 优先权： US61/432,070 20110112
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; C07D403/12 ; C07D223/14 ; A61K31/55 ; A61P37/00
摘要：
Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
