Invention Application
WO2012116145A1 NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS
审中-公开
用作抗糖尿病药物的新型CYABAZABENZIMIDAZOLE衍生物
- Patent Title: NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS
- Patent Title (中): 用作抗糖尿病药物的新型CYABAZABENZIMIDAZOLE衍生物
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Application No.: PCT/US2012/026261Application Date: 2012-02-23
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Publication No.: WO2012116145A1Publication Date: 2012-08-30
- Inventor: ANAND, Rajan , APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , CHU, Lin , COLANDREA, Vincent, J. , DONG, Guizhen , DROPINSKI, James, F. , FENG, Danqing , HICKS, Jacqueline, D. , JIANG, Jinlong , KIM, Alexander, J. , LEAVITT, Kenneth, J. , LI, Bing , QIAN, Xiaoxia , SEBHAT, Iyassu , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
- Applicant: MERCK SHARP & DOHME CORP. , ANAND, Rajan , APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , CHU, Lin , COLANDREA, Vincent, J. , DONG, Guizhen , DROPINSKI, James, F. , FENG, Danqing , HICKS, Jacqueline, D. , JIANG, Jinlong , KIM, Alexander, J. , LEAVITT, Kenneth, J. , LI, Bing , QIAN, Xiaoxia , SEBHAT, Iyassu , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
- Applicant Address: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- Assignee: MERCK SHARP & DOHME CORP.,ANAND, Rajan,APGAR, James, M.,BIFTU, Tesfaye,CHEN, Ping,CHU, Lin,COLANDREA, Vincent, J.,DONG, Guizhen,DROPINSKI, James, F.,FENG, Danqing,HICKS, Jacqueline, D.,JIANG, Jinlong,KIM, Alexander, J.,LEAVITT, Kenneth, J.,LI, Bing,QIAN, Xiaoxia,SEBHAT, Iyassu,WEI, Lan,WILKENING, Robert, R.,WU, Zhicai
- Current Assignee: MERCK SHARP & DOHME CORP.,ANAND, Rajan,APGAR, James, M.,BIFTU, Tesfaye,CHEN, Ping,CHU, Lin,COLANDREA, Vincent, J.,DONG, Guizhen,DROPINSKI, James, F.,FENG, Danqing,HICKS, Jacqueline, D.,JIANG, Jinlong,KIM, Alexander, J.,LEAVITT, Kenneth, J.,LI, Bing,QIAN, Xiaoxia,SEBHAT, Iyassu,WEI, Lan,WILKENING, Robert, R.,WU, Zhicai
- Current Assignee Address: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- Agency: MERCK SHARP & DOHME CORP.
- Priority: US61/446,551 20110225
- Main IPC: A01N43/58
- IPC: A01N43/58
Abstract:
Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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