An interface system (10) for man-machine interaction, comprising a sensor and actuator arrangement (12) wearable by or couplable to the body (B) of a user; and a management unit (14) provided for exchanging data with a control application resident on a remote processing system (PS), in such a way as to transmit data to the application, indicative of the position and movements of the user in a physical environment, and in such a way as to transmit sensations to the user, in at least one point of the body of the user, indicative of the interaction with an operating environment. The sensors and actuators are supported by a plurality of operating modules (16), facing on at least one communication channel through respective pairs of input and output communication ports. The operating modules are provided with interconnection devices (18) in such a way as to be assemblable to each other into a planar arrangement and/or a stacked arrangement.