Invention Application
- Patent Title: INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM
- Patent Title (中): 细菌III型分泌系统的抑制剂
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Application No.: PCT/US2012/046693Application Date: 2012-07-13
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Publication No.: WO2013010089A2Publication Date: 2013-01-17
- Inventor: MOIR, Donald, T. , AIELLO, Daniel , PEET, Norton, P. , WILLIAMS, John, D. , TORHAM, Matthew
- Applicant: MICROBIOTIX, INC. , MOIR, Donald, T. , AIELLO, Daniel , PEET, Norton, P. , WILLIAMS, John, D. , TORHAM, Matthew
- Applicant Address: One Innovation Drive Worcester, MA 01605 US
- Assignee: MICROBIOTIX, INC.,MOIR, Donald, T.,AIELLO, Daniel,PEET, Norton, P.,WILLIAMS, John, D.,TORHAM, Matthew
- Current Assignee: MICROBIOTIX, INC.,MOIR, Donald, T.,AIELLO, Daniel,PEET, Norton, P.,WILLIAMS, John, D.,TORHAM, Matthew
- Current Assignee Address: One Innovation Drive Worcester, MA 01605 US
- Agency: YANKWICH, Leon, R. et al.
- Priority: US61/507,402 20110713
- Main IPC: A61K31/4741
- IPC: A61K31/4741
Abstract:
Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
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