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发明申请
WO2013066134A3 NOVEL CINNAMYL-RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS 审中-公开
新型的茜素衍生物和包含其作为活性成分的药物组合物

NOVEL CINNAMYL-RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS
摘要：
The present invention relates to cinnamyl-rhodanine derivative compounds or pharmaceutically acceptable salts thereof, and to a pharmaceutical composition comprising the compounds as active ingredients. More particularly, cinnamyl-rhodanine derivative compounds of the present invention inhibit the migration of cancer cells through an inhibition of activity of protein phosphatase (PPase) of PRL-3(phosphatase of regenerating liver), and therefore, can be valuably used in preventing or treating metastasis of cancer. Further, cinnamyl-rhodanine derivative compounds of the present invention inhibit the migration of vascular endothelial cells and thus inhibit angiogenesis by the same mechanism, and therefore, can be valuably used in preventing or treating angiogenesis-related diseases caused by anticancer drug or abnormal angiogenesis.
摘要（中）：

本发明涉及肉桂酰 - 绕丹宁衍生物化合物或其药学上可接受的盐，以及包含该化合物作为活性成分的药物组合物。 更具体地，本发明的肉桂酰 - 绕丹宁衍生物化合物通过抑制PRL-3（再生肝的磷酸酶）的蛋白磷酸酶（PPase）的活性而抑制癌细胞的迁移，因此可以有价值地用于预防或 治疗癌症转移。 此外，本发明的肉桂酰 - 绕丹宁衍生物化合物抑制血管内皮细胞的迁移，从而通过相同的机制抑制血管生成，因此可以有价值地用于预防或治疗由抗癌药物引起的血管发生相关疾病或异常血管生成。

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