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    NOVEL CINNAMYL-RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS
    2.
    发明申请
    NOVEL CINNAMYL-RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS 审中-公开
    新型的茜素衍生物和包含其作为活性成分的药物组合物

    公开(公告)号：WO2013066134A3

    公开(公告)日：2013-06-27

    申请号：PCT/KR2012009249

    申请日：2012-11-05

    申请人： KOREA RES INST OF BIOSCIENCE

    发明人： KWON BYOUNG MOG ,  HAN DONG CHO ,  HAN YOUNG MIN

    IPC分类号： C07D277/36 ,  A61K31/426 ,  A61P35/00 ,  C07D277/34

    CPC分类号： A61K31/426 ,  A61K45/06 ,  C07D277/36 ,  A61K2300/00

    摘要： The present invention relates to cinnamyl-rhodanine derivative compounds or pharmaceutically acceptable salts thereof, and to a pharmaceutical composition comprising the compounds as active ingredients. More particularly, cinnamyl-rhodanine derivative compounds of the present invention inhibit the migration of cancer cells through an inhibition of activity of protein phosphatase (PPase) of PRL-3(phosphatase of regenerating liver), and therefore, can be valuably used in preventing or treating metastasis of cancer. Further, cinnamyl-rhodanine derivative compounds of the present invention inhibit the migration of vascular endothelial cells and thus inhibit angiogenesis by the same mechanism, and therefore, can be valuably used in preventing or treating angiogenesis-related diseases caused by anticancer drug or abnormal angiogenesis.

    摘要翻译： 本发明涉及肉桂酰 - 绕丹宁衍生物化合物或其药学上可接受的盐，以及包含该化合物作为活性成分的药物组合物。 更具体地，本发明的肉桂酰 - 绕丹宁衍生物化合物通过抑制PRL-3（再生肝的磷酸酶）的蛋白磷酸酶（PPase）的活性而抑制癌细胞的迁移，因此可以有价值地用于预防或 治疗癌症转移。 此外，本发明的肉桂酰 - 绕丹宁衍生物化合物抑制血管内皮细胞的迁移，从而通过相同的机制抑制血管生成，因此可以有价值地用于预防或治疗由抗癌药物引起的血管发生相关疾病或异常血管生成。

    ANTIBODY-BINDING PEPTIDE-FERRITIN FUSION PROTEIN AND USES THEREOF
    4.
    发明申请
    ANTIBODY-BINDING PEPTIDE-FERRITIN FUSION PROTEIN AND USES THEREOF 审中-公开
    抗体结合肽 - 铁蛋白融合蛋白及其应用

    公开(公告)号：WO2013055058A2

    公开(公告)日：2013-04-18

    申请号：PCT/KR2012007993

    申请日：2012-10-02

    申请人： KOREA RES INST OF BIOSCIENCE ,  UNIST ACADEMY IND RES CORP

    发明人： CHUNG SANG JEON ,  KANG SE BYUNG ,  KANG HYO JIN ,  KANG YOUNG JI ,  LEE YOUNG MI

    IPC分类号： A61K38/00 ,  A61K9/16 ,  A61K39/395 ,  A61K47/48

    CPC分类号： A61K49/1818 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00

    摘要： The present invention relates to nanoparticles including 24 antibody-binding peptide-ferritin fusion protein monomers, the nanoparticles being characterized in that six partial structures having a 4-fold symmetry point are formed due to ferritin, and an antibody-binding peptide is fused to the ferritin in a range of ±10 a.a. of the 4-fold symmetry point such that 4 antibody-binding peptides are positioned in the vicinity of the 4-fold symmetry point; and also relates to uses of the nanoparticles. The present invention can be used for biochips, drug delivery systems, disorder diagnosis, and the development of treating agents by producing the fusion protein through the introduction of the sequence of the antibody-binding peptide into the ferritin, and using the fusion protein to allow the antibody to strongly bind to the ferritin without any damage to the antibody structure.

    摘要翻译： 本发明涉及包含24个抗体结合性肽 - 铁蛋白融合蛋白单体的纳米颗粒，所述纳米颗粒的特征在于由于铁蛋白而形成了具有4重对称点的六个部分结构，并且抗体结合肽与 铁蛋白在±10 aa的范围内 的4倍对称点，使得4个抗体结合肽位于4倍对称点附近; 并且还涉及纳米颗粒的用途。 本发明可以通过将抗体结合性肽的序列导入铁蛋白制作融合蛋白，使用该融合蛋白使其可以用于生物芯片，给药系统，障碍诊断，治疗药物的开发等 抗体与铁蛋白强烈结合而对抗体结构没有任何损害。

    PROBE FOR IFRET AND USAGE OF SAME
    5.
    发明申请
    PROBE FOR IFRET AND USAGE OF SAME 审中-公开
    探索和使用它们

    公开(公告)号：WO2012177106A3

    公开(公告)日：2013-04-11

    申请号：PCT/KR2012005009

    申请日：2012-06-25

    申请人： KOREA RES INST OF BIOSCIENCE ,  CHUNG SANG JEON ,  KIM JU HWAN ,  RUCHKINA ELENA ,  KANG HYO JIN

    发明人： CHUNG SANG JEON ,  KIM JU HWAN ,  RUCHKINA ELENA ,  KANG HYO JIN

    IPC分类号： G01N33/52 ,  C09K11/06 ,  G01N21/64 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/582 ,  G01N21/6428 ,  G01N33/542 ,  G01N33/573 ,  G01N2021/6441 ,  G01N2458/00

    摘要： The present invention relates to a probe for iFRET and to a usage of same. More particularly, the present invention relates to the probe for iFRET, a method for manufacturing the probe for iFRET, a method for searching a target protein-specific binding site or a molecule having the binding site using the probe for iFRET, and a method for imaging the target protein through the probe for iFRET. The probe for iFRET, according to the present invention, unlike the existing FRET method, uses an amino acid inside a protein as a fluorescence donor, thereby using only one fluorescent substance, and has an light emitting wavelength which is separated from a protein intrinsic fluorescence, thereby having high specificity and sensitivity and thus allowing easier and more accurate analysis of the amount, activity, and mechanism, among others, of a variety of proteins.

    摘要翻译： 本发明涉及一种用于iFRET的探针及其用途。 更具体地，本发明涉及用于iFRET的探针，用于制造用于iFRET的探针的方法，使用所述iFRET探针来搜索靶蛋白特异性结合位点或具有所述结合位点的分子的方法，以及用于 通过iFRET的探针成像靶蛋白。 根据本发明的用于iFRET的探针与现有的FRET方法不同，使用蛋白质内部的氨基酸作为荧光供体，从而仅使用一种荧光物质，并且具有与蛋白质固有荧光分离的发光波长 ，因此具有高特异性和灵敏度，因此允许更容易且更准确地分析各种蛋白质的量，活性和机制等。

    PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASE CONTAINING AN ARDISIA TINCTORIA EXTRACT OR A FRACTION THEREOF AS AN ACTIVE INGREDIENT
    6.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASE CONTAINING AN ARDISIA TINCTORIA EXTRACT OR A FRACTION THEREOF AS AN ACTIVE INGREDIENT 审中-公开
    用于预防和治疗炎性疾病的药物组合物，所述炎性疾病包含无花果提取物提取物或其组分作为活性成分

    公开(公告)号：WO2012177081A3

    公开(公告)日：2013-04-04

    申请号：PCT/KR2012004957

    申请日：2012-06-22

    申请人： KOREA RES INST OF BIOSCIENCE ,  AHN KYUNG SEOP ,  KWON OK-KYOUNG ,  OH SEI RYANG ,  KIM JUNG HEE ,  LE XUAN CANH ,  PARK JI WON ,  LEE SANG WOO ,  LEE JOONGKU ,  LEE HYEONG KYU ,  CHOI SANG HO ,  TRAN THE BACH

    发明人： AHN KYUNG SEOP ,  KWON OK-KYOUNG ,  OH SEI RYANG ,  KIM JUNG HEE ,  LE XUAN CANH ,  PARK JI WON ,  LEE SANG WOO ,  LEE JOONGKU ,  LEE HYEONG KYU ,  CHOI SANG HO ,  TRAN THE BACH

    IPC分类号： A61K36/185 ,  A61P17/00 ,  A61P29/00

    CPC分类号： A61K36/185

    摘要： The present invention relates to a composition for preventing and treating inflammatory disease containing an Ardisia tinctoria (Ardisia tinctoria Pit.) extract or a fraction thereof as an active ingredient. More specifically, it has been confirmed that an Ardisia tinctoria extract or a fraction thereof suppresses the production of nitric oxide which is sharply increased by inflammation induction, and it has been confirmed that the Ardisia tinctoria extract is effective in markedly reducing the amount of PGE2, IL-6 (interleukin-6) and IL-1 beta cytokine in a dose dependent fashion, and that it inhibits the expression of iNOS and the COX2 gene and protein and inhibits nuclear translocation of p65 protein and phosphorylation of signal transducers. Also, it has been confirmed that the Ardisia tinctoria extract and an ethyl acetate fraction are effective in suppressing inflammation in a carrageenan-induced mouse podedema model as well. Consequently, the Ardisia tinctoria extract or fraction can be used to advantage as an active ingredient in compositions for preventing and treating or alleviating inflammatory related diseases, or compositions for topical skin preparations, cosmetic compositions and health foods.

    摘要翻译： 本发明涉及一种用于预防和治疗炎症性疾病的组合物，其含有作为活性成分的紫金藤（Ardisia tinctoria Pit。）提取物或其部分。 更具体地说，已经证实，紫金藤提取物或其部分抑制由炎症诱导急剧增加的一氧化氮的产生，并且已经证实紫金藤提取物有效地显着减少PGE 2的量， IL-6（白细胞介素-6）和IL-1β细胞因子以剂量依赖性方式抑制iNOS和COX2基因和蛋白质的表达，抑制p65蛋白质的核易位和信号转导子的磷酸化。 此外，已经证实，色情植物提取物和乙酸乙酯部分对于抑制角叉菜胶诱导的小鼠神经胶质瘤模型中的炎症也是有效的。 因此，紫金菊提取物或部分可以有利地用作用于预防和治疗或缓解炎性相关疾病的组合物中的活性成分，或用于局部皮肤制剂，化妆品组合物和健康食品的组合物。

    NANOPOSITIONING SUBSTRATE PREPARATION APPARATUS AND PREPARATION METHOD USING DIP PEN NANOLITHOGRAPHY WITH SINGLE OR MULTIPLE TIPS USING ATOMIC FORCE MICROSCOPE (AFM)
    7.
    发明申请
    NANOPOSITIONING SUBSTRATE PREPARATION APPARATUS AND PREPARATION METHOD USING DIP PEN NANOLITHOGRAPHY WITH SINGLE OR MULTIPLE TIPS USING ATOMIC FORCE MICROSCOPE (AFM) 审中-公开
    使用原子力显微镜（AFM）的单笔或多个提示使用DIP笔纳米尺度的纳米基板制备装置和制备方法

    公开(公告)号：WO2012173343A3

    公开(公告)日：2013-04-04

    申请号：PCT/KR2012003994

    申请日：2012-05-21

    申请人： KOREA RES INST OF BIOSCIENCE ,  HA TAI-HWAN ,  PARK JEE-EUN

    发明人： HA TAI-HWAN ,  PARK JEE-EUN

    IPC分类号： G01N33/48 ,  B82B3/00 ,  G01Q60/24 ,  G01Q80/00

    CPC分类号： B05C11/00 ,  B05D5/00 ,  B81C99/0025 ,  B82Y10/00 ,  G01Q80/00 ,  G03F7/0002

    摘要： The present invention relates to dip pen nanolithography technique which is an imaging method using a atomic force microscope, and more specifically, to a preparation apparatus and a preparation method for a nanopositioning substrate of an ink system using dip pen nanolithography with a single or multiple tips. According to the present invention, with respect to the imaging method using the atomic force microscope, provided is the preparation apparatus and the preparation method for the nanopositioning substrate of the ink system using dip pen nanolithography with single or multiple tips, comprising: a first ink storage portion and a second ink storage portion for coating a tip with an ink; a first washing portion and a second washing portion for washing the tip coated with an ink; a pattern carving portion for carving a tip on a substrate; an electrode connection portion for applying voltage; and a position checking portion for checking or determining the position of the coated tip on a micrometer-scale area, wherein the position checking portion is formed to check position through the change of a voltage-current, the extent of bending of an AFM tip with respect to voltage and an AFM image; and it is possible to increase the density of a biomaterial on the micrometer-scale area by integrating a large number of the biomaterial on the substrate by using the reproducibility of the atomic force microscope tip position.

    摘要翻译： 本发明涉及一种使用原子力显微镜的成像方法的浸笔纳米光刻技术，更具体地说，涉及一种使用具有单个或多个尖端的浸笔纳米光刻技术的墨水系统的纳米定位基板的制备装置和制备方法 。 根据本发明，关于使用原子力显微镜的成像方法，提供了使用具有单个或多个尖端的浸笔纳米光刻技术的墨水系统的纳米定位基板的制备装置和制备方法，包括：第一墨 存储部分和用墨水涂覆末端的第二墨水储存部分; 第一洗涤部分和用于清洗涂有油墨的尖端的第二清洗部分; 用于在基板上雕刻尖端的图案雕刻部分; 用于施加电压的电极连接部分; 以及位置检查部分，用于检查或确定涂覆的尖端在微米尺度区域上的位置，其中位置检查部分形成为通过电压 - 电流的变化来检查位置，AFM尖端的弯曲程度 对电压和AFM图像; 并且可以通过使用原子力显微镜尖端位置的再现性将大量的生物材料整合到基板上，从而增加微米尺度区域上的生物材料的密度。

    CRYSTAL STRUCTURE AND PEPTIDE INHIBITORS OF HAUSP DEUBIQUITINASE
    8.
    发明申请
    CRYSTAL STRUCTURE AND PEPTIDE INHIBITORS OF HAUSP DEUBIQUITINASE 审中-公开
    HAUSP DEUBIQUITINASE的晶体结构和肽抑制剂

    公开(公告)号：WO2012141794A3

    公开(公告)日：2013-03-14

    申请号：PCT/US2012026198

    申请日：2012-02-22

    申请人： UNIV SOUTHERN CALIFORNIA ,  KOREA RES INST OF BIOSCIENCE & BIOTECHNOLOGY ,  JUNG JAE ,  LEE HYE-RA ,  KIM MYUNG HEE ,  OH TAE-KWANG ,  HWANG JUNG-WON

    发明人： JUNG JAE ,  LEE HYE-RA ,  KIM MYUNG HEE ,  OH TAE-KWANG ,  HWANG JUNG-WON

    IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K48/00 ,  A61P35/00

    CPC分类号： A61K39/42 ,  A61K38/55 ,  C07K14/005 ,  C07K2299/00 ,  C12N2710/16422 ,  C12Q1/37 ,  G01N33/574 ,  G01N2500/02

    摘要： Two vIRF4 (Kaposi's-sarcoma-associated-herpesvirus vIRF4) peptides, vif1, corresponding to aa202-216 of vIRF4, and vif2, corresponding to aa220-236 of vIRF4, are potent and selective HAUSP antagonists. The vif1 and vif2 peptides robustly suppress HAUSP DUB enzymatic activity, ultimately leading to p53 -mediated anti-cancer activity. The vif1 and vif2 peptides, along with their homologues, are useful in treating cancer through regulation of p53 activity in a cancer cell. Also disclosed is the crystalline structure of vIRF4-HAUSP TRAF domain complex. The structure is useful in computer aided drug design for identifying an agent that interacts with and inhibits HAUSP, resulting in p53 medicated cell cycle arrest of cancer cells.

    摘要翻译： 对应于vIRF4的aa202-216的vIRF4（卡波西 - 肉瘤相关疱疹病毒vIRF4）肽vif1和对应于vIRF4的a220-236的vif2是有效和选择性的HAUSP拮抗剂。 vif1和vif2肽强力抑制HAUSP DUB酶活性，最终导致p53介导的抗癌活性。 vif1和vif2肽及其同源物可用于通过调节癌细胞中p53活性来治疗癌症。 还公开了vIRF4-HAUSP TRAF结构域复合物的晶体结构。 该结构在计算机辅助药物设计中有用，用于鉴定与HAUSP相互作用并抑制HAUSP的药剂，导致癌细胞的p53药物细胞周期停滞。

    INTERSPECIFIC AND INTRASPECIFIC CHLORELLA STRAIN MICROSATELLITE MOLECULAR MARKER
    9.
    发明申请
    INTERSPECIFIC AND INTRASPECIFIC CHLORELLA STRAIN MICROSATELLITE MOLECULAR MARKER 审中-公开
    特异性和特异性CHLORELLA菌株微生物分子标记

    公开(公告)号：WO2012177089A3

    公开(公告)日：2013-02-21

    申请号：PCT/KR2012004970

    申请日：2012-06-22

    申请人： KOREA RES INST OF BIOSCIENCE ,  OH HEE MOCK ,  JO BEOM HO ,  AHN CHI YONG ,  LEE SEUNG HOON ,  CHOI GANG GUK

    发明人： OH HEE MOCK ,  JO BEOM HO ,  AHN CHI YONG ,  LEE SEUNG HOON ,  CHOI GANG GUK

    IPC分类号： C12N15/11 ,  C12Q1/68

    CPC分类号： C12Q1/6895 ,  C12Q2600/156

    摘要： The present invention relates to a microsatellite marker for Chlorella, and more particularly, to a novel microsatellite molecular marker capable of interspecific and intraspecific classification of micro-algae Chlorella strains and to a primer for amplifying same. The Chlorella-derived novel microsatellite molecular marker of the present invention may enable analysis of the polymorphism genotype of an allele on the basis of the number of repetitions of a short base sequence existing in Chlorella genes, thus not only enabling interspecific classification of several Chlorella species having close phylogenetic relationships but also enabling clear intraspecific classification of Chlorella strains within an identical species. Therefore, the marker of the present invention can be used as an interspecific classification marker for Chlorella or a marker for distinguishing intraspecific strains.

    摘要翻译： 本发明涉及一种用于小球藻的微卫星标记，更具体地说，涉及能够对微藻小球藻菌株进行种间和种内分类的新颖的微卫星分子标记，以及用于扩增微藻的引物。 本发明的来自小球藻的新型微卫星分子标记物可以基于存在于小球藻基因中的短碱基序列的重复次数来分析等位基因的多态性基因型，因此不仅能够实现几种小球藻物种的种间分类 具有密切的系统发育关系，但也能使相同物种内的小球藻菌株能够清晰地进行种内分类。 因此，本发明的标记物可以用作小球藻的种间分类标记或区分种内菌株的标记物。