Invention Application
WO2013176955A1 CARDIOPROTECTIVE COMPOUNDS, THEIR USE WITH CHEMOTHERAPY, AND METHODS FOR IDENTIFYING THEM
审中-公开
保护性化合物，其与化疗有关的使用方法及其鉴定方法
- Patent Title: CARDIOPROTECTIVE COMPOUNDS, THEIR USE WITH CHEMOTHERAPY, AND METHODS FOR IDENTIFYING THEM
- Patent Title (中): 保护性化合物，其与化疗有关的使用方法及其鉴定方法
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Application No.: PCT/US2013/041334Application Date: 2013-05-16
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Publication No.: WO2013176955A1Publication Date: 2013-11-28
- Inventor: PETERSON, Randall, T. , LIU, Yan
- Applicant: THE GENERAL HOSPITAL CORPORATION , PETERSON, Randall, T. , LIU, Yan
- Applicant Address: 55 Fruit Street Boston, MA 02114 US
- Assignee: THE GENERAL HOSPITAL CORPORATION,PETERSON, Randall, T.,LIU, Yan
- Current Assignee: THE GENERAL HOSPITAL CORPORATION,PETERSON, Randall, T.,LIU, Yan
- Current Assignee Address: 55 Fruit Street Boston, MA 02114 US
- Agency: HALSTEAD, David, P. et al.
- Priority: US61/780,338 20130313; US61/649,626 20120521
- Main IPC: A61K31/122
- IPC: A61K31/122 ; A61K31/136 ; A61K31/704 ; A61K31/353 ; A61K31/37
Abstract:
The invention provides a method of reducing anthracycline-induced cardiotoxicity by administering a toxicity-reducing compound, such as a compound of Formulas (I), (II) or (III) or a combination thereof, and/or diphenyl urea (DPU), dexrazoxane (DEX), to a patient receiving an anthracycline. The invention also provides a method of identifying toxicity-reducing compounds.
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