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公开(公告)号：WO2023076899A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/078656
申请日：2022-10-25
摘要： A method and system for assessing tissue to determine a presence or absence of cancer cells. The method includes acquiring fluorescence lifetime (FLT) data from tissue and processing the FLT data to determine a FLT signal at each of a plurality of locations across the tissue. The method also includes determining FLT data at any of the plurality of locations above a threshold indicative a presence of cancer cells and generating a report indicating any of the plurality of locations above the threshold as indicative the presence of cancer cells.
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公开(公告)号：WO2023064528A1
公开(公告)日：2023-04-20
申请号：PCT/US2022/046663
申请日：2022-10-14
摘要： Disclosed herein are methods that allow for treating sleep apnea by removing adipose tissue and increasing collagen production in a patient's upper airways by injecting ice slurry comprising ingredients such as sterile water, a biocompatible surfactant such as glycerol, and saline into the target area.
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公开(公告)号：WO2023060256A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/077789
申请日：2022-10-07
发明人： JOUNG, J. Keith , GRÜNEWALD, Julian , MILLER, Bret
摘要： Described herein are split and reduced size CRISPR Prime Editors, as well as variant reverse transcriptases, and methods of use thereof.
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公开(公告)号：WO2023059704A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/045764
申请日：2022-10-05
摘要： An access device includes an access assembly for percutaneously accessing an anatomical space in a patient. An aspiration assembly is operable to generate negative pressure in a fluidic channel of the device. The fluidic channel places the access assembly in fluid connection with the aspiration assembly. A fluid tube has a first tube end connected to the access assembly, a second tube end connected to the aspiration assembly, and a tube body. The tube body defines a manometer tube portion spaced apart from both the first and second tube ends. The manometer tube portion acts as at least part of a manometer when the device is in a manometer mode. The manometer tube portion has adjacent first and second manometer tube ends and an inflection point substantially reversing the direction of the manometer tube portion at a location spaced apart from both the first and second manometer tube ends.
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公开(公告)号：WO2023028032A1
公开(公告)日：2023-03-02
申请号：PCT/US2022/041171
申请日：2022-08-23
发明人： THRAPP, Andrew, D. , AHSEN, Osman, O. , TEARNEY, Guillermo, J. , JAFFER, Farouc, A. , GARDECKI, Joseph, A. , KASSAB, Mohamad, B. , MAUSKAPF, Adam
摘要： A method for detecting inflammatory activity, including: providing a catheter including a near-infrared fluorescence (NIRF) imaging system configured to perform NIRF imaging and an optical coherence tomography (OCT) imaging system configured to perform structural imaging; introducing a near-infrared fluorescent cathepsin-activatable imaging agent into a blood vessel; placing a distal end of the catheter within the blood vessel; obtaining, using the OCT imaging system, structural images of an atherosclerotic plaque within the blood vessel; obtaining, using the NIRF imaging system, NIRF images of the atherosclerotic plaque within the blood vessel; detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images; and identifying inflammation within the atherosclerotic plaque based on detecting the near- infrared fluorescent cathepsin-activatable imaging agent in the NIRF images.
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公开(公告)号：WO2022269050A1
公开(公告)日：2022-12-29
申请号：PCT/EP2022/067380
申请日：2022-06-24
发明人： FASANO, Alessio , GROSS, Gabriele , MANURUNG, Sarmauli Irianti , SENGER, Stefania , VAN TOL, Eric Alexander Franciscus
IPC分类号： A61K38/17 , A61P1/00 , A61P29/00 , A23J1/202 , A23J3/325 , A23J3/344 , A23L33/00 , A23L33/40 , A23V2200/32 , A23V2250/54246 , A61K38/018 , A61K38/1709 , A61K9/14 , A61P37/06 , A61P37/08
摘要： The present application relates to extensively hydrolysed protein, and compositions comprising extensively hydrolysed protein, for use in reducing the risk of intestinal inflammation, reducing the risk of intestinal tissue damage, and/or improving gut barrier function, in an infant.
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公开(公告)号：WO2022261481A2
公开(公告)日：2022-12-15
申请号：PCT/US2022/033081
申请日：2022-06-10
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE GENERAL HOSPITAL CORPORATION
发明人： HACOHEN, Nir , GENTILI, Matteo , LIU, Bingxu
IPC分类号： C12N15/113 , C07K14/47 , C12N2310/20 , C12N2320/12
摘要： Provided herein are compositions and methods for enhancing the activity of Stimulator of Interferon Genes (STING) with one or more agents for inhibiting the activity of one or more negative regulators of STING, including DNAJC13 and ESCRT.
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公开(公告)号：WO2022251824A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/072524
申请日：2022-05-24
IPC分类号： A61K31/18 , A61K31/505 , A61K31/5377 , A61P37/00
摘要： Aspects of the present disclosure provide methods for treating allergic inflammatory diseases, such as allergic asthma and atopic dermatitis, using inhibitors of matrix metalloproteinase 13 (MMP13) such as small molecule inhibitors of MMP13.
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公开(公告)号：WO2022241470A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/072310
申请日：2022-05-13
申请人： THE GENERAL HOSPITAL CORPORATION , CARAVAN, Peter , NING, Yingying , MA, Hua , SHUVAEV, Sergey , AKAM, Eman
发明人： CARAVAN, Peter , NING, Yingying , MA, Hua , SHUVAEV, Sergey , AKAM, Eman
IPC分类号： C07D255/02 , A61K49/06 , C07D257/02 , A61B6/037 , C07D401/12 , C07D417/12 , C07D471/08
摘要： Disclosed herein are methods of molecular magnetic resonance (MR) imaging and positron emission tomography using extracellular probes that target extracellular allysine aldehyde and act as a noninvasive biomarker of fibrogenesis with high sensitivity and specificity in detecting fibrogenesis, for example, in rodent models and human fibrotic tissues.
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公开(公告)号：WO2022236225A2
公开(公告)日：2022-11-10
申请号：PCT/US2022/071859
申请日：2022-04-22
IPC分类号： H01L29/84 , B81B3/00 , F15C5/00 , B01L2400/0638 , B01L3/502738 , F16K99/0026 , F16K99/0059 , F16K99/0061
摘要： A fluidic transistor comprising: a flow region configured to transport a first fluid; a gate region configured to contain a second fluid; and a deformable region disposed between the flow and gate regions, wherein the deformable region is configured to induce flow-limitation as the first fluid is transported within the flow region.
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