发明申请
- 专利标题： ANTHRAQUINONE ANALOGS AND METHODS OF MAKING AND USING THEREOF
- 专利标题（中）： 蒽醌类似物及其制备和使用方法
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申请号： PCT/US2013/049898申请日： 2013-07-10
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公开(公告)号： WO2014011753A2公开(公告)日： 2014-01-16
- 发明人: WANG, Binghe , DAI, Chaofeng , DRAGANOV, Alexander , YANG, Xiaochuan , SUN, Guojing , YANG, Chunhao , CHEN, Weixuan , NI, Nanting , ZHOU, Muxiang , GU, Lubing
- 申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , EMORY UNIVERSITY , CHILDREN'S HEALTHCARE OF ATLANTA
- 申请人地址： 30 Courtland Street NE Suite 217 Atlanta, GA 30303 US
- 专利权人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.,EMORY UNIVERSITY,CHILDREN'S HEALTHCARE OF ATLANTA
- 当前专利权人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.,EMORY UNIVERSITY,CHILDREN'S HEALTHCARE OF ATLANTA
- 当前专利权人地址： 30 Courtland Street NE Suite 217 Atlanta, GA 30303 US
- 代理机构： PABST, Patrea, L. et al.
- 优先权： US61/669,927 20120710
- 主分类号： C07C50/34
- IPC分类号： C07C50/34
摘要：
Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.
