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公开(公告)号：WO2014011753A2
公开(公告)日：2014-01-16
申请号：PCT/US2013/049898
申请日：2013-07-10
Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , EMORY UNIVERSITY , CHILDREN'S HEALTHCARE OF ATLANTA
Inventor： WANG, Binghe , DAI, Chaofeng , DRAGANOV, Alexander , YANG, Xiaochuan , SUN, Guojing , YANG, Chunhao , CHEN, Weixuan , NI, Nanting , ZHOU, Muxiang , GU, Lubing
IPC: C07C50/34
CPC classification number: C07C233/33 , C07C66/02 , C07C69/95 , C07C225/36 , C07C233/31 , C07C235/16 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C247/12 , C07C255/19 , C07C311/08 , C07C323/60 , C07C2603/24 , C07D213/56 , C07D213/61 , C07D213/70 , C07D261/08 , C07D267/12 , C07D295/15 , C07D307/54 , C07D333/24
Abstract: Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.
Abstract translation: 本文描述了表现出抗癌增殖活性的特异性抗癌细胞的大黄酸类似物。 在一些实施方案中，化合物包含平面或平面环系统。 通过促进化合物与DNA复合物的非共价结合，例如通过嵌入，这种环系统。 在一些实施方案中，化合物包含如上所述的平面或平面环体系和一个或多个取代基，其是烷基化部分，亲电基团或迈克尔受体或含有一个或多个烷基化部分，亲电子基团和/或迈克尔受体的基团。 本文所述的化合物还可以包含一个以上官能团以改善化合物的溶解度。
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公开(公告)号：WO2023011668A1
公开(公告)日：2023-02-09
申请号：PCT/CN2022/117379
申请日：2022-09-06
Applicant: 中国医学科学院医药生物技术研究所
IPC: C07C50/38 , C07C49/743 , C07C50/34 , C07D317/26 , C07D309/22 , A61P31/12 , A61P31/14 , A61P31/20 , A61P31/22 , C12R1/66 , C12P15/00 , A61P35/00
Abstract: 本发明公开了一种萘嵌苯酮类化合物及其应用。该类化合物能够与E3泛素连接酶三基序25（TRIM25）结合，促进TRIM25识别病原体，诱导病原体蛋白发生蛋白酶体依赖的泛素化降解，有望用作TRIM25的配体，实现更广泛的应用，例如用于制备PROTAC分子，因此，该类化合物具有非常好的研发价值和应用前景。
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公开(公告)号：WO2009016083A1
公开(公告)日：2009-02-05
申请号：PCT/EP2008/059681
申请日：2008-07-24
Applicant: CIBA HOLDING INC. , CIBA S.P.A. , SALA, Massimiliano , WUNDERLICH-WIPPERT, Wiebke , GARDI, Stefano
Inventor： SALA, Massimiliano , WUNDERLICH-WIPPERT, Wiebke , GARDI, Stefano
IPC: C07C69/00 , C07C50/34 , C07C311/17 , C07D209/48 , C07C235/84 , C08G63/685 , C08G63/688 , C08G65/34 , C08L101/00 , C08K5/08 , C08K5/3417 , C08K5/12
CPC classification number: C08G63/6886 , C07C50/34 , C07C69/593 , C07C69/712 , C07C235/84 , C07C311/17 , C07C2601/14 , C07C2603/24 , C07D209/48 , C08G63/6856 , C08G65/40 , C08G65/4012 , C08K5/0033 , C08K5/3417
Abstract: Disclosed are a method for improving the degradation of natural and/or synthetic polymers or a polymer article made from such polymer(s) by light and/or heat and/or humidity, comprising the incorporation of a compound of formula (I) into said natural and/or synthetic polymers: Formula (I); wherein m is 1 or 2, n is 1 to 100, X is selected from certain benzophenone-derived moieties and R, R1; R2 are each selected from list of certain residues; novel compounds of said formula (I) and polymeric articles of improved degradability in the presence of light and/or heat and/or humidity being made of a composition comprising: A) a natural and/or a synthetic polymer and B) a degradation accelerator being a compound of said formula (I).
Abstract translation: 公开了一种改善天然和/或合成聚合物或由这种聚合物通过光和/或热和/或湿度制成的聚合物制品的降解的方法，包括将式（I）化合物引入所述 天然和/或合成聚合物：式（I）; 其中m为1或2，n为1至100，X选自某些二苯甲酮衍生的部分，R，R 1; R2各自选自某些残基的列表; 所述式（I）的新型化合物和在光和/或热和/或湿度存在下具有改善的降解性的聚合物制品由包含以下组合物制成：A）天然和/或合成聚合物和B）降解促进剂 是所述式（I）的化合物。
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4.发明申请METHOD FOR PREPARING SUBSTITUTED ANTHRAQUINONE AND APPLICATION TO THE PREPARATION OF RHEINS 审中-公开制备取代的蒽醌的方法及其制备方法
公开(公告)号：WO98033757A1
公开(公告)日：1998-08-06
申请号：PCT/FR1998/000189
申请日：1998-02-02
IPC: C07C46/00 , A61K31/12 , C07C20060101 , C07C46/02 , C07C49/593 , C07C50/18 , C07C50/34 , C07C50/38 , C07C51/377 , C07C51/62 , C07C66/02 , C07C67/08 , C07C69/12 , C07C69/95
Abstract: The invention concerns a novel method for preparing substituted anthraquinone represented by the general formula (I) in which R represents a hydrogen atom or a linear or branched alkyl group of 1 to 5 carbon atoms, a chloromethyl group, a -COCl group, a COOR' group or a -CH2OR' group in which R' is a hydrogen atom or a linear or branched alkyl group of 1 to 5 carbon atoms, R1 represents a hydrogen atom, a hydroxyl group, a linear or branched alkyl group of 1 to 5 carbon atoms, or an acyloxy group of 1 to 5 carbon atoms, and R2 represents a hydrogen atom, by Diels-Alder reaction between a 1,4-naphthoquinone of general formula (II): in which R2 is as defined above, and X represents a hydrogen or halogen atom and an acyclic diene of formula (III): CH2 = CR - CH -OR2 in which R is as defined above, and R3 represents a silyl group of formula -Si(R4)3 in which R4 is a linear or branched alkyl group of 1 to 5 carbon atoms, followed by an oxidising deprotecting reaction using Jones reagent for obtaining substituted anthraquinone of general formula (I). The invention is for preparing rheins useful in pharmaceutics.
Abstract translation: 本发明涉及一种制备由通式（I）表示的取代的蒽醌的新方法，其中R表示氢原子或1至5个碳原子的直链或支链烷基，氯甲基，-COCl基，COOR '基团或-CH 2 OR'基团，其中R'为氢原子或具有1至5个碳原子的直链或支链烷基，R1表示氢原子，羟基，1至5个直链或支链烷基 碳原子或1〜5个碳原子的酰氧基，R2表示氢原子，通过通式（II）的1,4-萘醌（其中R2如上所定义）与狄尔斯 - 阿尔德反应，X 表示式（III）的氢或卤素原子和无环二烯：CH 2 = CR-CH -OR 2，其中R如上所定义，R 3表示式-Si（R 4）3的甲硅烷基，其中R 4是 直链或支链的1至5个碳原子的烷基，然后用Jones试剂进行氧化脱保护反应 得到通式（I）的取代蒽醌。 本发明用于制备用于制药的大黄酸。
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5.发明申请METHOD OF PREPARING A 2-ALKYL-4-ALKYLAMINO-1-HYDROXY-9,10-ANTHRACENEDIONE 审中-公开制备2-烷基-4-烷基亚氨基-1-羟基-9,10-蒽二酸的方法
公开(公告)号：WO2016207252A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/064479
申请日：2016-06-22
Applicant: AMAZON TECHNOLOGIES, INC. , LEGUIJT, Robin
Inventor： LEGUIJT, Robin , VAN DER SLUIS, Marcel
IPC: C07C221/00 , C07C225/36 , C07C46/00 , C07C50/34
CPC classification number: C07C225/36 , C07C46/00 , C07C221/00 , C07C2603/24 , C07C50/34
Abstract: A method of preparing a compound represented by general formula (3) : Formula (3). R 1 and R 2 are each independently an alkyl group. The method includes reacting a compound represented by general formula (2) : Formula (2) with an alkylamine represented by general formula (4) : H 2 N-R 2 (4).
Abstract translation: 制备由通式（3）表示的化合物：式（3）的方法。 R1和R2各自独立地为烷基。 该方法包括使由通式（2）表示的化合物：式（2）与由通式（4）表示的烷基胺：H2N-R2（4）反应。
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Patent Agency Ranking
公开(公告)号：WO2014011753A3
公开(公告)日：2014-04-17
申请号：PCT/US2013049898
申请日：2013-07-10
Applicant: UNIV GEORGIA STATE RES FOUND , UNIV EMORY , CHILDRENS HEALTHCARE ATLANTA
Inventor： WANG BINGHE , DAI CHAOFENG , DRAGANOV ALEXANDER , YANG XIAOCHUAN , SUN GUOJING , YANG CHUNHAO , CHEN WEIXUAN , NI NANTING , ZHOU MUXIANG , GU LUBING
IPC: C07C50/34 , C07C50/38 , C07C69/95 , C07C225/24 , C07C233/31 , C07C233/33 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C255/27 , C07C311/08 , C07C323/22 , C07D211/06 , C07D213/50
CPC classification number: C07C233/33 , C07C66/02 , C07C69/95 , C07C225/36 , C07C233/31 , C07C235/16 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C247/12 , C07C255/19 , C07C311/08 , C07C323/60 , C07C2603/24 , C07D213/56 , C07D213/61 , C07D213/70 , C07D261/08 , C07D267/12 , C07D295/15 , C07D307/54 , C07D333/24
Abstract: Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.
Abstract translation: 本文描述了表现出抗增殖活性，特别是抗癌细胞的大黄酸类似物。 在一些实施方案中，化合物含有平坦或平面环体系。 这样的环体系通过促进化合物与DNA复合物的非共价结合，例如通过插入。 在一些实施方案中，化合物含有如上所述的平坦或平面环体系和一个或多个烷基化部分，亲电子基团或迈克尔受体或包含一个或多个烷基化部分，亲电子基团和/或迈克尔受体的基团的取代基。 本文所述的化合物还可以含有一个或多个官能团以改善化合物的溶解度。
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7.发明申请METHOD FOR PREPARING ALIZARIN DERIVATIVE COMPOUND, NOVEL ALIZARIN DERIVATIVE COMPOUND, SURFACE MODIFICATION METHOD, PHOTOELECTRIC CONVERSION FILM, PHOTOELECTRIC CONVERSION ELEMENT, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR 审中-公开制备ALIZARIN衍生化合物的方法，新颖的利拉霉素衍生化合物，表面改性方法，光电转换膜，光电转换元件和电摄影光电子
公开(公告)号：WO2011071130A1
公开(公告)日：2011-06-16
申请号：PCT/JP2010/072181
申请日：2010-12-03
Applicant: FUJIFILM Corporation , TAKAHASHI, Keita , NII, Kazumi , YAGI, Kazunari
Inventor： TAKAHASHI, Keita , NII, Kazumi , YAGI, Kazunari
CPC classification number: H01L51/005 , C07C46/00 , C09B1/08 , C09B1/14 , C09B57/008 , G03G5/142 , H01L51/4273 , Y02E10/549 , C07C50/34
Abstract: The present invention provides a novel alizarin derivative compound and a simplified and low cost method for preparing an alizarin derivative compound including: obtaining a compound represented by Formula (2) using a compound represented by Formula (3); and obtaining an alizarin derivative compound represented by Formula (1) using the compound represented by Formula (2); in Formulae (1) to (3), R 1 represents a hydrogen atom or a substituent; n represents an integer of 1 to 3, L represents a specific alkyl group; Q represents an atomic group needed to form an aromatic ring or a heteroaromatic ring with adjacent carbon atoms; and P represents an atomic group which includes an atom(s) selected from a hydrogen atom, a carbon atom, an oxygen atom, a sulfur atom, a silicon atom and a boron atom, and which is needed to form a ring structure group with adjacent two oxygen atoms and two carbon atoms; Formula (1) Formula (2) Formula (3).
Abstract translation: 本发明提供一种新颖的茜素衍生物化合物和制备茜素衍生物化合物的简便成本低的方法，包括：使用由式（3）表示的化合物获得由式（2）表示的化合物; 并使用式（2）表示的化合物获得由式（1）表示的茜素衍生物化合物。 在式（1）至（3）中，R 1表示氢原子或取代基; n表示1〜3的整数，L表示特定的烷基。 Q表示形成具有相邻碳原子的芳环或杂芳环所需的原子团; P表示包含选自氢原子，碳原子，氧原子，硫原子，硅原子和硼原子的原子的原子团，形成环结构基团所需的 相邻的两个氧原子和两个碳原子; 式（1）式（2）式（3）。
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8.发明申请ラン科植物から分離した新規物質、これを含む抽出物、抗酸化剤、抗菌剤、抗癌剤及び抗炎症剤 审中-公开从ORCHIDACEOUS植物分离的新物质，以及提取物，抗氧化剂，抗菌剂，抗感染剂和含有抗菌药物的抗炎药物
公开(公告)号：WO2012004875A1
公开(公告)日：2012-01-12
申请号：PCT/JP2010/061608
申请日：2010-07-08
IPC: C07C50/34 , A01N35/06 , A01P3/00 , A61K31/122 , A61K36/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P39/06
CPC classification number: A61K36/898 , A01N35/06 , C07C50/34 , A01N65/40
Abstract: 【課題】副作用を起こすことなく、有効な抗酸化作用を有する抗酸化剤を提供する。 【解決手段】下記式（１）で示される新規物質。
Abstract translation: [问题]提供具有有效抗氧化作用而不显示任何副作用的抗氧化剂。 [溶液]式（1）表示的新型物质。
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9.发明申请
公开(公告)号：WO2005113478A3
公开(公告)日：2008-12-18
申请号：PCT/US2005016501
申请日：2005-05-11
Applicant: UNIV MICHIGAN STATE , NAIR MURALEEDHARAN G , DHANANJEYAN MUGUNTHU R , KRON MICHAEL A , MILEV YOULI
Inventor： NAIR MURALEEDHARAN G , DHANANJEYAN MUGUNTHU R , KRON MICHAEL A , MILEV YOULI
Abstract: A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.
Abstract translation: 描述了制备羟基取代的蒽醌的方法。 该方法将邻苯二甲酸酐（取代或未取代的）与至少两个羟基取代的苯环部分结合。 剩余的羟基在一些蒽醌中转化为甲氧基。 该化合物特别可用于治疗寄生虫病。 另外，使用蒽醌治疗或预防疟疾，丝虫病血吸虫病和其他寄生虫病的方法。
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10.发明申请
公开(公告)号：WO2005113478A2
公开(公告)日：2005-12-01
申请号：PCT/US2005016501
申请日：2005-05-11
Applicant: UNIV MICHIGAN STATE , NAIR MURALEEDHARAN G , DHANANJEYAN MUGUNTHU R , KRON MICHAEL A , MILEV YOULI
Inventor： NAIR MURALEEDHARAN G , DHANANJEYAN MUGUNTHU R , KRON MICHAEL A , MILEV YOULI
Abstract: A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.
Abstract translation: 描述了制备羟基取代的蒽醌的方法。 该方法将邻苯二甲酸酐（取代或未取代的）与至少两个羟基取代的苯环部分结合。 剩余的羟基在一些蒽醌中转化为甲氧基。 该化合物特别可用于治疗寄生虫病。 另外，使用蒽醌治疗或预防疟疾，丝虫病血吸虫病和其他寄生虫病的方法。
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