Invention Application
WO2014036654A1 COMPOUNDS AND METHODS FOR SELECTIVELY TARGETING CANCER STEM CELLS
审中-公开
用于选择性靶向癌细胞的化合物和方法
- Patent Title: COMPOUNDS AND METHODS FOR SELECTIVELY TARGETING CANCER STEM CELLS
- Patent Title (中): 用于选择性靶向癌细胞的化合物和方法
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Application No.: PCT/CA2013/050688Application Date: 2013-09-06
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Publication No.: WO2014036654A1Publication Date: 2014-03-13
- Inventor: BHATIA, Mickie , COLLINS, Tony
- Applicant: MCMASTER UNIVERSITY
- Applicant Address: McMaster Industry Liaison Office (MILO) MIP Suite 305 175 Longwood Road South Hamilton, Ontario L8P 0A1 CA
- Assignee: MCMASTER UNIVERSITY
- Current Assignee: MCMASTER UNIVERSITY
- Current Assignee Address: McMaster Industry Liaison Office (MILO) MIP Suite 305 175 Longwood Road South Hamilton, Ontario L8P 0A1 CA
- Agency: BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.
- Priority: US61/697,573 20120906
- Main IPC: A61K38/12
- IPC: A61K38/12 ; A61K31/519 ; A61K31/7048 ; A61P35/00
Abstract:
Described are compounds and methods useful for selectively targeting cancer stem cells. The compounds preferentially induce differentiation and/or reduce the proliferation of cancer stem cells relative to normal stem cells. Compounds useful for selectively targeting cancer stem cells include polyene macrolides such as Nystatin or Amphotericin B, analogs thereof and pharmaceutically acceptable salts thereof.
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