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    MAGNETIC MICROGEL BEADS, METHODS OF MAKING AND USES THEREOF
    1.
    发明申请
    MAGNETIC MICROGEL BEADS, METHODS OF MAKING AND USES THEREOF 审中-公开

    公开(公告)号：WO2023082021A1

    公开(公告)日：2023-05-19

    申请号：PCT/CA2022/051679

    申请日：2022-11-14

    Applicant: MCMASTER UNIVERSITY

    Inventor： SOLEYMANI, Leyla ,  HOARE, Todd ,  LI, Yingfu ,  LU, Yang ,  PANDEY, Richa

    IPC: G01N33/553 ,  C12Q1/68 ,  G01N33/531 ,  G01N21/66 ,  G01N21/76 ,  G01N27/416

    Abstract: This disclosure relates to magnetic microgel beads, and in particular to magnetic microgel beads for biofunctionalization and methods of making and uses thereof, for example, in biosensing assays. In an embodiment, a magnetic microparticle comprising a magnetic nanoparticle encapsulated by a polymer hydrogel. In another embodiment, an assay for detecting the presence of a target analyte in a sample comprising a) the magnetic microparticle disclosed herein, wherein the biorecognition agent further comprises a reporter moiety; b) an electrochemical chip comprising a working electrode, a counter electrode and a reference electrode; and c) a capture probe functionalized on the working electrode; wherein binding of the biorecognition agent to the target analyte results in production of an electrochemical, electroluminescent or photoelectrochemical signal.

    CATALYST FREE, RAPID CURE SILICONE ELASTOMERS
    5.
    发明申请
    CATALYST FREE, RAPID CURE SILICONE ELASTOMERS 审中-公开

    公开(公告)号：WO2021012048A1

    公开(公告)日：2021-01-28

    申请号：PCT/CA2020/051013

    申请日：2020-07-22

    Applicant: MCMASTER UNIVERSITY

    Inventor： BROOK, Michael A. ,  BUI, Robert

    IPC: C08G77/388 ,  C08J3/24 ,  C08K5/07 ,  C08L83/08

    Abstract: The present application provides a method for the rapid, catalyst-free, preparation of silicone elastomers using aminoalkylsilicones and aliphatic aldehydes that can dissolve in water at a concentration of at least 2 wt.%, in air or under water. The elastomers prepared by this method have good hydrolytic stability and can be used as hydrophobic adhesives or sealants under water.

    NUCLEIC ACID ENZYME-MEDIATED SIGNAL AMPLIFICATION FOR BIOSENSING
    9.
    发明申请
    NUCLEIC ACID ENZYME-MEDIATED SIGNAL AMPLIFICATION FOR BIOSENSING 审中-公开

    公开(公告)号：WO2018161177A1

    公开(公告)日：2018-09-13

    申请号：PCT/CA2018/050294

    申请日：2018-03-12

    Applicant: MCMASTER UNIVERSITY

    Inventor： LI, Yingfu ,  BRENNAN, John ,  LIU, Meng

    IPC: C12Q1/6844 ,  C12Q1/68 ,  C12Q1/682

    Abstract: Described is an approach that takes advantage of rolling circle amplification (RCA) and an RNA-cleaving DNAzyme (RCD) to achieve massive signal amplification for biosensing via a cross-feedback mechanism. An RCA reaction generates copies of an RCD that triggers a reaction cascade designed to generate additional DNA assemblies for RCA. These cross- feedback actions work autonomously to turn limited molecular recognition events into massive amounts of DNA amplicons that can be conveniently detected. This approach was demonstrated for biosensing of a microRNA sequence and a bacterium.

    TEXTURED ELECTRODES WITH ENHANCED ELECTROCHEMICAL SENSITIVITY
    10.
    发明申请
    TEXTURED ELECTRODES WITH ENHANCED ELECTROCHEMICAL SENSITIVITY 审中-公开
    具有增强的电化学敏感性的纹理电极

    公开(公告)号：WO2017185186A1

    公开(公告)日：2017-11-02

    申请号：PCT/CA2017/050519

    申请日：2017-04-28

    Applicant: MCMASTER UNIVERSITY

    Inventor： GABARDO, Christine ,  ADAMS-MCGAVIN, Robert Chris ,  SOLEYMANI, Leyla

    IPC: G01N27/30

    Abstract: An all-solution electrode fabrication process is provided, The process comprises the steps of: i) preparing and activating a shrinkable polymer substrate for deposition of a conductive film; ii) modifying the substrate to incorporate a linker; iii) immobilizing particles of a conductive material on the linkers of the substrate to form a conductive film on the substrate; and vi) heating the modified substrate to a temperature sufficient to cause contraction of the polymer substrate and to result in micro- and/or nano-texturing in the conductive film. The process advantageously yields a novel multi-scale electrode device comprising a polymer substrate; and a textured electro- conductive film linked to the substrate.

    Abstract translation: 本发明提供了一种全溶液电极制造工艺。该工艺包括以下步骤：i）制备并激活用于沉积导电膜的可收缩聚合物基底; ii）修饰底物以掺入接头; iii）将导电材料的颗粒固定在基底的连接体上以在基底上形成导电膜; 和vi）将改性基材加热到足以引起聚合物基材收缩并在导电膜中导致微米和/或纳米纹理化的温度。 该方法有利地产生了包含聚合物基材的新型多尺度电极装置; 和连接到基板的纹理导电膜。

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