Invention Application
WO2014135561A1 NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP1 1 B2 OR CYP1 1 B1 ) INHIBITORS
审中-公开
新的二氢喹啉-2-酮衍生物作为醛固酮合成酶（CYP1 1 B2或CYP1 B1B）抑制剂
- Patent Title: NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP1 1 B2 OR CYP1 1 B1 ) INHIBITORS
- Patent Title (中): 新的二氢喹啉-2-酮衍生物作为醛固酮合成酶（CYP1 1 B2或CYP1 B1B）抑制剂
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Application No.: PCT/EP2014/054210Application Date: 2014-03-05
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Publication No.: WO2014135561A1Publication Date: 2014-09-12
- Inventor: AEBI, Johannes , AMREIN, Kurt , HORNSPERGER, Benoit , KUHN, Bernd , MAERKI, Hans P. , MAYWEG, Alexander V. , TAN, Xuefei
- Applicant: F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
- Applicant Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Assignee: F. HOFFMANN-LA ROCHE AG,HOFFMANN-LA ROCHE INC.
- Current Assignee: F. HOFFMANN-LA ROCHE AG,HOFFMANN-LA ROCHE INC.
- Current Assignee Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Agency: BERNARD, Guillaume
- Priority: CNPCT/CN2013/072348 20130308
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/10 ; A61K31/4709 ; A61K31/506 ; A61P5/40 ; A61P9/04 ; A61P9/12 ; A61P13/12
Abstract:
The invention provides novel compounds having the general formula (1) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , R 11 and A are as described herein, compositions including the compounds and methods of using the compounds. The compounds of formula (I) are useful as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment of various disorders.
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