-
公开(公告)号：WO2021048241A1
公开(公告)日：2021-03-18
申请号：PCT/EP2020/075259
申请日：2020-09-10
发明人： COLLIN, Ludovic , EDELMANN, Martin , GOBBI, Luca , GRETHER, Uwe , HARTUNG, Thomas , HE, Yingfang , HONER, Michael , HORNSPERGER, Benoit , KROLL, Carsten , MU, Linjing , MURI, Dieter , O'HARA, Fionn , RICHTER, Hans , RITTER, Martin
IPC分类号： C07D498/04 , C07B59/00 , A61P25/16 , A61P25/28 , A61P35/00 , A61K31/5365
摘要： The invention provides new radiolabeled monoacylglycerol lipase (MAGL) inhibitors that are useful for medical imaging, such as positron-emission tomography (PET), single-photon emission computed tomography (SPECT) and/or autoradiography.
-
公开(公告)号：WO2016066664A1
公开(公告)日：2016-05-06
申请号：PCT/EP2015/074925
申请日：2015-10-28
发明人： AEBI, Johannes , AMREIN, Kurt , HORNSPERGER, Benoit , KUHN, Bernd , LI, Dongbo , LIU, Yongfu , MAERKI, Hans P. , MARTIN, Rainer E. , MAYWEG, Alexander V. , TAN, Xuefei , WANG, Lisha , WU, Jun
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D231/18 , C07D401/04 , C07D401/12 , C07D405/04 , C07D413/12 , C07D417/04 , A61K31/4155 , A61P13/12 , A61P9/00
CPC分类号： C07D417/04 , C07D231/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R 1 , R 2 and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R 1，R 2和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
-
3.发明申请PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE 审中-公开作为阿托品酮合成酶抑制剂的苯基二氢吡啶衍生物
公开(公告)号：WO2015055602A1
公开(公告)日：2015-04-23
申请号：PCT/EP2014/071940
申请日：2014-10-14
发明人： AEBI, Johannes , AMREIN, Kurt , BRITTON, Robert , HORNSPERGER, Benoit , KUHN, Bernd , MAERKI, Hans P. , MARTIN, Rainer E. , MAYWEG, Alexander V. , TAN, Xuefei
IPC分类号： C07D221/04 , A61K31/435 , A61P9/04 , A61P5/40 , A61P9/12 , A61P13/12
CPC分类号： A61K31/472 , C07D217/02 , C07D221/04 , C07D401/12 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , A 1 and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，A1和n如本文所述，包括化合物和 使用化合物的方法。
-
4.发明申请NEW 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS 审中-公开新的3,4-二氢-2H-异喹啉-1-酮和2,3-二氢-1-茚满-1-酮化合物
公开(公告)号：WO2014191338A1
公开(公告)日：2014-12-04
申请号：PCT/EP2014/060790
申请日：2014-05-26
发明人： AEBI, Johannes , AMREIN, Kurt , CHEN, Wenming , HORNSPERGER, Benoit , KUHN, Bernd , LIU, Yongfu , MAERKI, Hans P. , MARTIN, Rainer E. , MAYWEG, Alexander V. , TAN, Xuefei , WANG, Lisha , ZHOU, Mingwei
IPC分类号： C07D401/14 , A61K31/4427 , A61P9/00 , A61P13/12
CPC分类号： C07D401/14
摘要： The invention provides novel compounds having the general formula (I) (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , A, m, n and p described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15， 本文所述的n和p，包括所述化合物的组合物和使用所述化合物的方法。
-
5.发明申请NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP1 1 B2 OR CYP1 1 B1 ) INHIBITORS 审中-公开新的二氢喹啉-2-酮衍生物作为醛固酮合成酶（CYP1 1 B2或CYP1 B1B）抑制剂
公开(公告)号：WO2014135561A1
公开(公告)日：2014-09-12
申请号：PCT/EP2014/054210
申请日：2014-03-05
发明人： AEBI, Johannes , AMREIN, Kurt , HORNSPERGER, Benoit , KUHN, Bernd , MAERKI, Hans P. , MAYWEG, Alexander V. , TAN, Xuefei
IPC分类号： C07D401/14 , C07D401/10 , A61K31/4709 , A61K31/506 , A61P5/40 , A61P9/04 , A61P9/12 , A61P13/12
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D413/14
摘要： The invention provides novel compounds having the general formula (1) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , R 11 and A are as described herein, compositions including the compounds and methods of using the compounds. The compounds of formula (I) are useful as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment of various disorders.
摘要翻译： 本发明提供具有通式（1）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 9，R 10，R 11和A如本文所述，包括该化合物的组合物和使用该化合物的方法。 式（I）化合物可用作治疗各种疾病的醛固酮合酶（CYP11B2或CYP11B1）抑制剂。
-
公开(公告)号：WO2022223750A1
公开(公告)日：2022-10-27
申请号：PCT/EP2022/060644
申请日：2022-04-22
发明人： AMOUSSA, Machoud , BENZ, Joerg , BRIAN, Niels Kevin , FRISTON, Kallie , GIROUD, Maude , GRETHER, Uwe , GROEBKE ZBINDEN, Katrin , HORNSPERGER, Benoit , KROLL, Carsten , KUHN, Bernd , LEAKE, Camiel John , MARTIN, Rainer E. , NIPPA, David Friedrich Erhard , O'HARA, Fionn Susannah , PUELLMANN, Bernd , RICHTER, Hans , RITTER, Martin , ROMBACH, Didier , SCHMID, Philipp Claudio , ZHANG, Shounan
IPC分类号： C07D403/14 , C07D407/14 , C07D413/14 , A61K31/4196 , A61K31/4245 , A61P35/00
摘要： The invention provides new heterocyclic compounds having the general formula (I), wherein A, B, X, and R1 to R7 are as described herein, compositions including thecompounds, processes of manufacturing the compounds and methods of using the compounds.
-
公开(公告)号：WO2021048242A1
公开(公告)日：2021-03-18
申请号：PCT/EP2020/075260
申请日：2020-09-10
发明人： BENZ, Joerg , GOBBI, Luca , GRETHER, Uwe , GROEBKE ZBINDEN, Katrin , HORNSPERGER, Benoit , KROLL, Carsten , KUHN, Bernd , MARTIN, Rainer E. , O'HARA, Fionn , PUELLMANN, Bernd , RICHTER, Hans , RITTER, Martin
IPC分类号： C07D498/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61K31/5383
摘要： The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L1, X, m, n, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as monoacylglycerol lipase (MAGL) inhibitors.
-
公开(公告)号：WO2019180185A8
公开(公告)日：2019-09-26
申请号：PCT/EP2019/057174
申请日：2019-03-22
发明人： BELL, Charles , BENZ, Joerg , GOBBI, Luca , GRETHER, Uwe , GROEBKE ZBINDEN, Katrin , HANSEN, Dennis Jul , HORNSPERGER, Benoit , KOCER, Buelent , KROLL, Carsten , KUHN, Bernd , O`HARA, Fionn , RICHTER, Hans , RITTER, Martin , TSUCHIYA, Satoshi , CHEN, Rui
IPC分类号： C07D498/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P25/06 , A61P25/08 , A61K31/5375
摘要： The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R 20 to R 23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
-
公开(公告)号：WO2019115660A1
公开(公告)日：2019-06-20
申请号：PCT/EP2018/084653
申请日：2018-12-13
发明人： BELL, Charles , BENZ, Joerg , GRETHER, Uwe , HORNSPERGER, Benoit , KOCER, Buelent , KUHN, Bernd , RICHTER, Hans , TSUCHIYA, Satoshi
IPC分类号： C07D413/14 , A61K31/538 , C07D413/06 , A61P25/00 , A61P35/00
摘要： The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R 1 , R 2 and R 3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
-
公开(公告)号：WO2017148967A1
公开(公告)日：2017-09-08
申请号：PCT/EP2017/054682
申请日：2017-03-01
摘要： The invention provides novel compounds having the general formula (I) wherein wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 3 , R 8 , R 9 , R 10 , R 11 , R 12 and R 23 are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供了具有通式（I）的新化合物，其中R 1，R 2，R 3，R 3，R 4，R 5， R 4，R 5，R 6，R 7，R 3，R 3，R 4，R 5，R 5，R 5， ，R 8，R 9，R 10，R 11，R 12， 和R 23如本文所述，包括所述化合物的组合物和使用所述化合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
45 条记录 (耗时 0.022 秒)
