Invention Application
WO2014169144A2 PHOSPHOKETOLASES FOE IMPROVED PRODUCTION OF ACETYL COENZYME A-DERIVED METABOLITES, ISOPRENE, ISOPRENOID PRECUROSORS, AND ISOPRENOIDS
审中-公开
磷酸烯醇酯改进了乙酰辅酶A衍生的代谢产物，异戊二烯，异戊烯前体和异戊二烯的生产
- Patent Title: PHOSPHOKETOLASES FOE IMPROVED PRODUCTION OF ACETYL COENZYME A-DERIVED METABOLITES, ISOPRENE, ISOPRENOID PRECUROSORS, AND ISOPRENOIDS
- Patent Title (中): 磷酸烯醇酯改进了乙酰辅酶A衍生的代谢产物，异戊二烯，异戊烯前体和异戊二烯的生产
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Application No.: PCT/US2014/033688Application Date: 2014-04-10
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Publication No.: WO2014169144A2Publication Date: 2014-10-16
- Inventor: BECK, Zachary, Q. , MUNOS, Jeffrey, W. , WELLS, Derek, H. , YAO, Jian
- Applicant: DANISCO US INC. , THE GOODYEAR TIRE & RUBBER COMPANY
- Applicant Address: 925 Page Mill Road Palo Alto, CA 94304-1013 US
- Assignee: DANISCO US INC.,THE GOODYEAR TIRE & RUBBER COMPANY
- Current Assignee: DANISCO US INC.,THE GOODYEAR TIRE & RUBBER COMPANY
- Current Assignee Address: 925 Page Mill Road Palo Alto, CA 94304-1013 US
- Agency: SHOW, Matthew, D. et al.
- Priority: US61/834,359 20130612; US61/810,696 20130410
- Main IPC: C07K14/435
- IPC: C07K14/435
Abstract:
This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
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