公开(公告)号：WO2014066851A1

公开(公告)日：2014-05-01

申请号：PCT/US2013/066960

申请日：2013-10-25

Applicant: GERON CORPORATION

Inventor： GRYAZNOV, Sergei, M. ,  ZIELINSKA, Daria ,  PRUZAN, Ronald, A. ,  LINDQUIST, Jeffrey, N.

IPC: C12N15/113 ,  A61K31/7125 ,  A61P35/00

CPC classification number: C12N15/1135 ,  A61K31/7125 ,  C12N2310/111 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/3515 ,  C12N2310/3517

Abstract: Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same. The antisense oligonucleotides comprise at least one phosphoramidate (NP)-modified or thiophosphoramidate (NPS)-modified intersubunit linkage.

Abstract translation: 本文提供的是可以有效预防或减少c-myc蛋白表达以及降低体外和哺乳动物细胞增殖性疾病体内模型中细胞增殖的总体速率的反义寡核苷酸，以及使用该方法。 反义寡核苷酸包含至少一种氨基磷酸酯（NP） - 修饰的或硫代磷酰胺（NPS）修饰的亚单位连接。

公开(公告)号：WO2014144016A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/028246

申请日：2014-03-14

Applicant: PLEXBIO CO., LTD. ,  TSAO, Dean

Inventor： TSAO, Dean ,  HUANG, Chin-Shiou

IPC: G01N33/551

CPC classification number: G01N33/54313

Abstract: The invention provided herein discloses, inter alia, compositions of beads (such as, polymeric beads) of substantially identical size and shape encoded with unique information storing identifiers and methods for use of the same in multiplex chemical and biological assays. Accordingly, provided herein are methods for conducting a multiplex assay comprising the steps of: a) contacting a sample with beads in an assay system, wherein each bead in the system comprises an identifier; wherein the system comprises (i) at least one bead with an identifier that is recognized by an imaging processor as a specific assay, and (ii) a plurality of beads, wherein each bead comprises a capture agent immobilized on the surface of the bead that specifically binds to an analyte; and simultaneously or sequentially, in any order: b) identifying the identifier that is recognized by the imaging processor as the specific assay; and c) detecting the binding of the analyte in the sample by analyzing the binding of the analyte to the capture agent immobilized on the surface of the bead based on the identification of the identifier as the specific assay.

Abstract translation: 本文提供的本发明特别地公开了具有基本上相同尺寸和形状的珠子（例如，聚合物珠粒）的组合物，其编码有存储标识符的唯一信息和用于多重化学和生物测定法的方法。 因此，本文提供了用于进行多重测定的方法，包括以下步骤：a）在测定系统中使样品与珠粒接触，其中系统中的每个珠粒包含标识符; 其特征在于，所述系统包括（i）具有标识符的至少一个珠粒，其由成像处理器识别为特定测定，和（ii）多个珠粒，其中每个珠粒包含固定在珠粒表面上的捕获剂， 特异性地结合分析物; 并且以任何顺序同时或顺序地：b）将由成像处理器识别的标识符识别为特定测定; 和c）通过基于识别标识符作为特异性测定来分析分析物与固定在珠粒表面上的捕获剂的结合来检测样品中分析物的结合。

公开(公告)号：WO2013115867A1

公开(公告)日：2013-08-08

申请号：PCT/US2012/063286

申请日：2012-11-02

Applicant: BIODESY, LLC

Inventor： SALAFSKY, Joshua, S. ,  MCGUINNESS, Ryan, P.

IPC: G01N33/52 ,  G01N33/483

CPC classification number: C12Q1/34 ,  C07K14/82 ,  C12Q1/42 ,  G01N2333/82 ,  G01N2333/916 ,  G01N2440/00 ,  G01N2458/00

Abstract: Provided herein are compositions and methods for identifying and detecting modulators of Ras protein conformational states through the use of second harmonic generation (SHG) technology. Also provided herein are methods for detecting a conformational changes in the three dimensional structure of a protein bound to a supported lipid bilayer.

Abstract translation: 本文提供了通过使用二次谐波产生（SHG）技术鉴定和检测Ras蛋白质构象状态的调节剂的组合物和方法。 本文还提供了检测结合到支持的脂质双层的蛋白质的三维结构中的构象变化的方法。

公开(公告)号：WO2011143637A1

公开(公告)日：2011-11-17

申请号：PCT/US2011/036552

申请日：2011-05-13

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a Body Corporate ,  KOVACS, James ,  HANNAN, Jonathan P. ,  HOLERS, V. Michael

Inventor： KOVACS, James ,  HANNAN, Jonathan P. ,  HOLERS, V. Michael

IPC: C07K14/705 ,  C07K19/00

CPC classification number: C07K19/00 ,  C07K14/472

Abstract: Provided herein are compositions and methods directed to soluble proteins which can selectively deliver modulators of complement activity. Targeted delivery of these modulators is accomplished by selectively mutating particular amino acids in a targeting protein portion of the composition corresponding to at least the first two N-terminal SCR domains of CR2. Depending on the particular combination of mutations introduced into the targeting portion, a complement activity modulator can be selectively delivered to particular ligands of CR2 at sites where complement system activation or suppression is desired.

Abstract translation: 本文提供了针对可选择性递送补体活性调节剂的可溶性蛋白质的组合物和方法。 这些调节剂的靶向递送通过选择性地突变组合物的靶蛋白部分中对应于CR2的至少前两个N末端SCR结构域的特定氨基酸而实现。 取决于引入靶向部分的突变体的特定组合，补体活性调节剂可以选择性递送到需要补体系统激活或抑制的位点处的CR2的特定配体。

公开(公告)号：WO2014153209A8

公开(公告)日：2014-09-25

申请号：PCT/US2014/029606

申请日：2014-03-14

Applicant: ANDES BIOTECHNOLOGIES S.A.

Inventor： BURZIO ERIZ, Luis O. ,  BURZIO MENENDEZ, Veronica A. ,  VILLEGAS OLAVARRIA, Jaime E.

IPC: C12N15/11 ,  C12N5/00 ,  C12N15/00 ,  A61K48/00

Abstract: The invention provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating and preventing metastasis or relapse of a cancer in an individual previously treated for cancer with a therapy. The invention also provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating a refractory cancer (e.g., a refractory HPV-associated cancer).

Abstract translation: 本发明提供了与非编码嵌合线粒体RNA互补的寡核苷酸以及包含其的组合物和试剂盒，以及它们在治疗和预防之前治疗过的个体中的癌症转移或复发中的用途 癌症与治疗。 本发明还提供了与非编码嵌合线粒体RNA互补的寡核苷酸以及包含其的组合物和试剂盒，以及它们在治疗难治性癌症（例如难治性HPV相关癌症）中的用途。

公开(公告)号：WO2014088785A1

公开(公告)日：2014-06-12

申请号：PCT/US2013/070437

申请日：2013-11-15

Applicant: GERON CORPORATION

Inventor： STUART, Monic, J. ,  KELSEY, Stephen

IPC: A61K31/7088 ,  A61K31/7125 ,  A61P35/00 ,  A61P35/02 ,  A61P7/00 ,  A61P7/06

CPC classification number: A61K31/7088 ,  A61K31/7125

Abstract: Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have myeloproliferative disorders, such as Essential Thrombocythemia (ET). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having myeloproliferative disorders, such as ET.

Abstract translation: 本文提供了用于减少肿瘤祖细胞增殖和缓解与诊断患有或被认为具有骨髓增生性疾病如基础性血小板增多症（ET）的个体相关的症状的方法。 本文还提供了使用端粒酶抑制剂在被诊断患有或怀疑具有骨髓增生性疾病如ET的个体的血液中在相对正常范围内维持血小板计数的方法。

公开(公告)号：WO2014169144A2

公开(公告)日：2014-10-16

申请号：PCT/US2014/033688

申请日：2014-04-10

Applicant: DANISCO US INC. ,  THE GOODYEAR TIRE & RUBBER COMPANY

Inventor： BECK, Zachary, Q. ,  MUNOS, Jeffrey, W. ,  WELLS, Derek, H. ,  YAO, Jian

IPC: C07K14/435

CPC classification number: C12N9/88 ,  C12P5/007 ,  C12P5/026 ,  C12P19/32 ,  C12Q1/527 ,  C12Y401/02009

Abstract: This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.

Abstract translation: 本发明涉及包含能够增加乙酰辅酶A衍生代谢物产生的异源磷酸酮醇酶（PKL）多肽的培养重组细胞以及生产和使用该培养重组细胞的方法。 在一些实施方案中，重组细胞还包含一种或多种甲羟戊酸（MVA）途径多肽，用于产生类异戊二烯前体，异戊二烯和类异戊二烯。

公开(公告)号：WO2013162654A1

公开(公告)日：2013-10-31

申请号：PCT/US2013/000117

申请日：2013-04-25

Applicant: BIODESY, LLC

Inventor： SALAFSKY, Joshua, S.

IPC: G01N33/68 ,  G01N33/58

CPC classification number: G01N33/542 ,  G01N2500/04

Abstract: The present invention discloses, inter alia, methods for labeling a target protein with an SHG-active probe for detection by second harmonic or sum-frequency generation in order to identify agents which bind to an allosteric site on the target protein thereby altering its structural conformation

Abstract translation: 本发明尤其公开了用用于通过二次谐波或和频产生检测的SHG活性探针标记靶蛋白的方法，以便鉴定与靶蛋白上的变构位点结合从而改变其结构构象的试剂

公开(公告)号：WO2018157072A1

公开(公告)日：2018-08-30

申请号：PCT/US2018/019750

申请日：2018-02-26

Applicant: LIFE TECHNOLOGIES CORPORATION ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： VARELA-ROHENA, Angel, M. ,  ANDOLINA, Melanie, B. ,  RILEY, James, L. ,  MEDVEC, Andrew

IPC: C12N5/0783

Abstract: This invention relates, inter alia , to compositions of low serum or serum free media and methods for the expansion of T cell populations and methods for using such populations of cells. In some aspects, the invention relates to compositions and methods for the selective expansion of T cell subpopulations.

公开(公告)号：WO2018058067A1

公开(公告)日：2018-03-29

申请号：PCT/US2017/053313

申请日：2017-09-25

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： GAENSLER, Karin

IPC: A61K38/19 ,  A61K39/00 ,  C12N15/864

Abstract: Provided herein, inter alia , are cell media compositions and whole cell vaccines comprising recombinant cells expressing IL-15, IL-15Rα, and CD80 capable of treating and preventing relapse in individuals diagnosed with or thought to have leukemia as well as methods for using the same.

Abstract translation: 本文提供的细胞培养基组合物和全细胞疫苗包含表达IL-15，IL-15Rα和CD80的重组细胞，其能够治疗和预防在 被诊断患有或被认为患有白血病的个体以及使用它的方法。