发明申请
WO2015089321A2 USE OF MULLERIAN INHIBITING SUBSTANCE (MIS) PROTEINS FOR CONTRACEPTION AND OVARIAN RESERVE PRESERVATION
审中-公开
使用MULLERIAN抑制物质（MIS）蛋白质进行收缩和OVARIAN RESERVE保存
- 专利标题： USE OF MULLERIAN INHIBITING SUBSTANCE (MIS) PROTEINS FOR CONTRACEPTION AND OVARIAN RESERVE PRESERVATION
- 专利标题（中）： 使用MULLERIAN抑制物质（MIS）蛋白质进行收缩和OVARIAN RESERVE保存
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申请号： PCT/US2014/069829申请日： 2014-12-11
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公开(公告)号： WO2015089321A2公开(公告)日： 2015-06-18
- 发明人: DONAHOE, Patricia, K. , PEPIN, David
- 申请人： THE GENERAL HOSPITAL CORPORATION
- 申请人地址： 55 Fruit St. Boston, Massachusetts 02114 US
- 专利权人： THE GENERAL HOSPITAL CORPORATION
- 当前专利权人： THE GENERAL HOSPITAL CORPORATION
- 当前专利权人地址： 55 Fruit St. Boston, Massachusetts 02114 US
- 代理机构： RESNICK, David, S. et al.
- 优先权： US61/914,671 20131211
- 主分类号： A61K38/17
- IPC分类号： A61K38/17
摘要：
One aspect of the invention provides a method of contraception by administering to a female subject a composition comprising Mullerian inhibiting substance (MIS). The MIS can be produced endogenously in the subject by a vector, where the vector comprises a polynucletide encoding a recombinant MIS protein. In some embodiments, the contraception is permanent and only requires administration of the composition once. Another aspect of the invention relates to a method of preserving an ovarian reserve, the method comprising administering to a female subject a composition comprising MIS or an inducible vector that comprises a polynucleotide encoding a recombinant MIS protein.
IPC分类:
