Invention Application
- Patent Title: LIVER X RECEPTOR AGONISTS IN THE TREATMENT OF EMPHYSEMA
- Patent Title (中): 肝脏X受体激动剂治疗恶性肿瘤
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Application No.: PCT/US2014/070941Application Date: 2014-12-17
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Publication No.: WO2015095386A1Publication Date: 2015-06-25
- Inventor: D'ARMIENTO, Jeanine , SKLEPKIEWICZ, Piotr , LEMAITRE, Vincent
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK , D'ARMIENTO, Jeanine , SKLEPKIEWICZ, Piotr , LEMAITRE, Vincent
- Applicant Address: West 116th Street & Broadway New York, NY 10027 US
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK,D'ARMIENTO, Jeanine,SKLEPKIEWICZ, Piotr,LEMAITRE, Vincent
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK,D'ARMIENTO, Jeanine,SKLEPKIEWICZ, Piotr,LEMAITRE, Vincent
- Current Assignee Address: West 116th Street & Broadway New York, NY 10027 US
- Agency: WHITE, John P.
- Priority: US61/917,319 20131217
- Main IPC: A61P11/00
- IPC: A61P11/00 ; G01N33/566
Abstract:
The present invention provides methods and compositions for treating a subject afflicted with chronic obstructive pulmonary disease (COPD) which comprise a i) a Liver X receptor (LXR) agonist, ii) a miR-33 antagonist, or iii) a TLR4/Myd88 pathway antagonist. The present invention also provides methods and compositions for use in prophylactically treating a subject for chronic obstructive pulmonary disease (COPD) which comprise i) a Liver X receptor (LXR) agonist, ii) a miR-33 antagonist, or iii) a TLR4/Myd88 pathway antagonist.
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