公开(公告)号：WO2023088287A1

公开(公告)日：2023-05-25

申请号：PCT/CN2022/132188

申请日：2022-11-16

申请人： ACROIMMUNE GUANGZHOU BIOTECH LTD

发明人： ZHOU, Qunmin ,  FANG, Xianfeng ,  LI, Dongling ,  MU, Libing ,  ZHOU, JianYing

IPC分类号： C07K16/28 ,  C07K16/32 ,  C12N15/63 ,  A61P15/00 ,  G01N33/566

摘要： The compositions of a glycosylated and/or sialylated core peptide (073 core) and compositions of proteins based on fusion of one or more copy of the peptide to the Fc fragment of human immunoglobulin and their use in treating diseases propagated by inflammation associated with tissue injuries or invading pathogens.

公开(公告)号：WO2023063717A1

公开(公告)日：2023-04-20

申请号：PCT/KR2022/015394

申请日：2022-10-12

申请人： 연세대학교 산학협력단

发明人： 박태선 ,  강위석

IPC分类号： G01N33/566 ,  C12Q1/6883

摘要： 본 발명은 피부 노화의 진단용 조성물에 관한 것으로, 본 발명의 조성물은 내인성 요인으로 인한 현재의 피부 노화 정도를 평가할 뿐 아니라, 향후 이러한 피부 노화가 진행될 유전적 위험성을 높은 신뢰도로 예측함으로써 피부 노화에 대한 개인별 맞춤 치료 전략을 조기에 수립하는 데에 유용하게 이용될 수 있다. 본 발명은 또한 피부 노화 개선제의 스크리닝 방법에 관한 것으로, 본 발명의 스크리닝 방법은 피부 진피(dermis)의 노화에 따라 감소된 진피 섬유아세포의 콜라겐 생성을 복원하여 피부 조직의 결합력 저하, 탄력 감소, 수분 상실 및 장벽기능 손상을 가역적으로 회복시킴으로써 수분 공급과 같은 대증적 요법을 넘어서는 근원적인 피부 노화 억제제를 정확하고 신속하게 탐색할 수 있다.

公开(公告)号：WO2022271264A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/025761

申请日：2022-04-21

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： NARGI, Frances ,  WICK, Scott, Thomas ,  MISHRA, Deepak

IPC分类号： G01N33/74 ,  C07K14/705 ,  C07K14/72 ,  G01N33/566 ,  C07K14/66 ,  C07K14/721 ,  C07K14/723 ,  C07K2319/03 ,  C07K2319/09 ,  C07K2319/50 ,  C12N15/625 ,  C12N9/0071 ,  C12Y114/14003 ,  G01N2333/726 ,  G01N33/5023

摘要： The invention relates to compositions and methods for making and use of a real-time cellular sensor. Components of a multipart enzyme are sequestered in different cellular compartments and only come together after receptor activation; a pool of substrate is made available in the cell to ensure real- time enzymatic output.

公开(公告)号：WO2022165576A1

公开(公告)日：2022-08-11

申请号：PCT/BR2022/050033

申请日：2022-02-03

申请人： CNPEM - CENTRO NACIONAL DE PESQUISA EM ENERGIA E MATERIAIS

发明人： TRINO ALBANO, Luciana Daniele ,  SIMÃO ALBANO, Luiz Gustavo ,  CAMPOS GRANATO, Daniela ,  GUIMARÃES SANTANA, Aline ,  STARNINI DE CAMARGO, Davi Henrique ,  CRISPILHO CORRÊA, Cátia ,  BOF BUFON, Carlos Cesar ,  PAES LEME, Adriana Franco

IPC分类号： G01N27/02 ,  G01N33/566 ,  G01N27/327

摘要： A presente descrição se refere a um biossensor sem marcação ( label-free ) com eletrodos interdigitados baseados em ZIF-8 para detecção de interações proteína-proteína. O processo de detecção com o referido biossensor se dá por medições de espectroscopia de impedância eletroquímica dos eletrodos. Também é descrito o processo de fabricação de tais biossensores, incluindo etapas de fabricação do eletrodo interdigitado (4), modificação do eletrodo com ZIF-8 (5), imobilização de uma proteína no eletrodo (6) e exposição do eletrodo a uma concentração de uma outra proteína, que é parceiro de interação da primeira, para detecção da interação entre as mesmas.

公开(公告)号：WO2022150834A2

公开(公告)日：2022-07-14

申请号：PCT/US2022/070081

申请日：2022-01-06

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： REYA, Tannishtha

IPC分类号： G01N33/58 ,  A61P35/02 ,  C07K14/36 ,  C07K2319/21 ,  C12Q1/6876 ,  G01N21/6428 ,  G01N33/542 ,  G01N33/566 ,  G01N33/582

摘要： Disclosed are methods for identifying small molecule modulators of protein-RNA interactions that could potentially function as therapeutic agents in cancer treatment. Methods of identifying inhibitors of the RNA-binding functions of MSI2, as well as inhibitors identified thereof, are also disclosed.

公开(公告)号：WO2022133107A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/063843

申请日：2021-12-16

申请人： COGNEXT DIAGNOSTICS LLC ,  THE JOHNS HOPKINS UNIVERSITY

发明人： WORLEY, Paul, F. ,  XIAO, Meifang ,  XU, Desheng

IPC分类号： G01N33/68 ,  C07K16/18 ,  G01N33/566 ,  G01N33/53

摘要： Disclosed herein are methods for diagnosing a subject as having a neurological disorder, such as Alzheimer's disease, using proximity-based detection assays capable of detecting complexes containing two or more synaptic proteins, such as neuronal pentraxins, from a blood, cerebrospinal fluid, or other fluid sample of the subject. Also disclosed are methods of evaluating and monitoring subjects having or at risk of developing a neurological disorder using the aforementioned assays.

公开(公告)号：WO2022117978A1

公开(公告)日：2022-06-09

申请号：PCT/GB2021/050083

申请日：2021-01-14

申请人： PARAYTEC LTD

发明人： SMYTHE, Carl Glenton Weymouth ,  GOODALL, David Murray

IPC分类号： G01N33/533 ,  G01N33/543 ,  G01N33/566 ,  G01N33/569 ,  G01N33/574

摘要： The present invention concerns the field of diagnostic testing to confirm the presence of target pathogens in a test sample, typically obtained from a human or animal. The test has particular application in testing for viruses, but could include cancer cells or other particulate pathogens, including bacteria. The disclosure provides a method for facilitating the detection of target pathogen particles in a test sample, the method comprising: providing one or more supports defining a support surface, the support surface being provided with a coating of a first set of macromolecular assemblies, the assemblies each being capable of selectively binding with the target pathogen particles, providing a second set of macromolecular assemblies, the assemblies also each being capable of binding selectively with the target pathogen particles, and wherein each of the second set of macromolecular assemblies is provided with at least one fluorophore moiety, obtaining or providing the test sample to be assayed for the presence of the target pathogen therein, exposing the macromolecular assemblies to the test sample so that target pathogen particles present in the test sample bind to the macromolecular assemblies, thereby producing a multitude of target pathogen particles distributed over and anchored to said support surface by members of the first set of macromolecular assemblies, with a plurality of fluorophore moieties being bound to each pathogen particle by members of the second set of macromolecular assemblies, so as to produce a fluorophore coating on anchored pathogen particles on the support. The invention provides assemblies of pathogen particles produced by this method. The methods may include a detection step for detecting fluorescence from bound fluorophores.

公开(公告)号：WO2022046728A2

公开(公告)日：2022-03-03

申请号：PCT/US2021/047283

申请日：2021-08-24

申请人： NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： PARK-MIN, Kyung-Hyun

IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N33/68 ,  C12Q1/00

摘要： Provided herein are methods of diagnosing and treating a skeletal disease in a subject. The method includes (i) identifying the presence of osteoclast-enhancing cells (OECs) in the subject; (ii) quantifying the number of circulating OECs in a sample from the subject; and (iii) diagnosing a skeletal disease in the subject when an increase in OECs is detected as compared to a control.

公开(公告)号：WO2022035989A1

公开(公告)日：2022-02-17

申请号：PCT/US2021/045592

申请日：2021-08-11

申请人： DEWPOINT THERAPEUTICS, INC.

发明人： MITREA, Diana Maria ,  MITTASCH, Matthäus ,  DANDLIKER, Peter Jeffrey ,  BEUTEL, Bruce Aaron ,  BOCZEK, Edgar Erik

IPC分类号： G01N33/566 ,  G01N33/58 ,  G01N33/50 ,  G01N33/68 ,  G01N21/17

摘要： In some aspects, provided herein are methods of identifying interactions of a compound and a condensate, or a component thereof, and uses thereof. In other aspects, provided herein are methods of identifying (or screening for or designing) compounds, or portions thereof, having a desired interaction with a condensate, or a component thereof. In yet other aspects, provided herein are applications of the methods described herein, e.g., libraries of compounds having known or predicted characteristics, and methods of identifying compounds useful for treatment of a disease.

公开(公告)号：WO2022020435A1

公开(公告)日：2022-01-27

申请号：PCT/US2021/042523

申请日：2021-07-21

申请人： FIRMENICH INCORPORATED

发明人： SERVANT, Guy

IPC分类号： G01N33/566 ,  A23L27/00 ,  C12Q1/6804

摘要： The present disclosure generally provides methods for imparting or enhancing an umami taste of a flavored article by introducing a compound that modulates a transmembrane (TM) region of a T1R taste receptor, such as the TM region of a T1r1 taste receptor. In some other aspects, the disclosure provides methods of identifying compounds that modulate a transmembrane (TM) region of a T1R taste receptor, and which thereby imparts or enhances an umami taste in a flavored article. In some other aspects, the disclosure provides compounds that modulate a transmembrane (TM) region of a T1R taste receptor, and their use in food or beverage products, in some cases, in combination with other compounds known to impart or enhance umami taste, such as glutamates, aspartates, and purinic ribonucleotides, such as inosine monophosphate (IMP) and guanosine monophosphate (GMP). In some aspects, the inclusion of such TM-region modulators in flavored products may allow one to reduce or eliminate the concentration of glutamate and aspartate in certain food and beverage products.