The present invention provides a method of treating a fermentation stream to remove dissolved gases, comprising obtaining a fermentation stream including water, one or more fermentation products, and dissolved gases; continuously sonicating the fermentation stream to generate acoustically cavitated gases from the dissolved gases; and applying vacuum to release the acoustically cavitated gases from the fermentation stream. The dissolved gases may include air, oxygen, nitrogen, helium, argon, carbon dioxide, carbon monoxide, hydrogen, or other non-condensables. The release of acoustically cavitated gases may optionally be done simultaneously with sonication. At least 75 %, such as up to 95 % or more, of the dissolved gases may be released from the fermentation stream. The disclosed method positively impacts downstream operations and product quality by removing dissolved gases.