发明申请
WO2016044655A2 FUSION PROTEINS, RECOMBINANT BACTERIA, AND METHODS FOR USING RECOMBINANT BACTERIA
审中-公开
融合蛋白,重组细菌和使用重组细菌的方法
- 专利标题: FUSION PROTEINS, RECOMBINANT BACTERIA, AND METHODS FOR USING RECOMBINANT BACTERIA
- 专利标题(中): 融合蛋白,重组细菌和使用重组细菌的方法
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申请号: PCT/US2015050795申请日: 2015-09-17
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公开(公告)号: WO2016044655A2公开(公告)日: 2016-03-24
- 发明人: THOMPSON BRIAN , SIEGEL ASHLEY
- 申请人: SPOGEN BIOTECH INC
- 专利权人: SPOGEN BIOTECH INC
- 当前专利权人: SPOGEN BIOTECH INC
- 优先权: US201462051885 2014-09-17
- 主分类号: C07K14/32
- IPC分类号: C07K14/32
摘要:
Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifiations of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g., for stimulating plant growth) are also provided.