发明申请
WO2016057560A1 POLARIZATION OF MACROPHAGES TO A HEALING PHENOTYPE BY CARDIOSPHERE-DERIVED CELLS AND BY THE EXOSOMES SECRETED BY SUCH CELLS
审中-公开
通过心脏细胞衍生的细胞和由这些细胞分泌的外来物质对健康对映体的极性偏振
- 专利标题： POLARIZATION OF MACROPHAGES TO A HEALING PHENOTYPE BY CARDIOSPHERE-DERIVED CELLS AND BY THE EXOSOMES SECRETED BY SUCH CELLS
- 专利标题（中）： 通过心脏细胞衍生的细胞和由这些细胞分泌的外来物质对健康对映体的极性偏振
-
申请号： PCT/US2015/054301申请日： 2015-10-06
-
公开(公告)号： WO2016057560A1公开(公告)日： 2016-04-14
- 发明人: MARBAN, Eduardo , DECOUTO, Geoffrey , TSELIOU, Eleni
- 申请人： CEDARS-SINAI MEDICAL CENTER
- 申请人地址： 8700 Beverly Boulevard Los Angeles, California 90048 US
- 专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人地址： 8700 Beverly Boulevard Los Angeles, California 90048 US
- 代理机构： CHEN, Stephen W. et al.
- 优先权： US62/060,481 20141006; US62/060,452 20141006
- 主分类号： A61P9/00
- IPC分类号： A61P9/00
摘要：
Described herein are compositions and techniques related to generation and therapeutic application of stem cell-derived exosomes. The Inventors have discovered cardiosphere-derived cells (CDCs) and their secreted exosomes mediate such inflammatory processes, by, for example, shifting macrophages away from a proinflammatory M1 phenotype toward M2 healing phenotype. This suggests compositions and techniques for use in both long-term reversal of heart and vascular disease pathology, and protection against such disease progression via modulation of inflammation and immune responses.
