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公开(公告)号：WO2023283637A2
公开(公告)日：2023-01-12
申请号：PCT/US2022/073558
申请日：2022-07-08
发明人： KORONYO, Maya , KORONYO, Yosef , BLACK, Keith L. , MIRZAEI, Nazanin , GAO, Liang
摘要： The present invention describes systems and method for the detection, diagnosis and monitoring of cognitive impairment and Alzheimer's disease. In one example, an integrated system comprising a full-field Fourier domain optical coherence tomography and an image mapping spectrometry is used for generating spectrally resolved volumetric images at wavelengths that show difference in spectral signatures of normal cells compared to spectral signatures of amyloid beta and pTau deposits, and also image inner retinal layers where amyloid beta and pTau deposits may aggregate.
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公开(公告)号：WO2022266022A1
公开(公告)日：2022-12-22
申请号：PCT/US2022/033315
申请日：2022-06-13
IPC分类号： A61F2/24
摘要： A heart valve prosthesis including separable ventricular and members is provided. The ventricular member has a first hub that has a connection feature. Each of at least three arms are coupled at a first end to the first hub and have a second end opposite the first end. The arms are preloaded toward a location of heart valve leaflet when the ventricular member is implanted. The atrial member has a second hub coupled to a frame array and has a connection feature configured to couple to the connection feature of the first hub for securing the atrial and ventricular members together. The frame array is preloaded toward a location of the heart valve leaflets when the atrial member is implanted. Concavities are formed at the periphery of the frame array to receive the arms of the ventricular member in an engaged configuration. Valve tissue may be trapped between the arms and the concavities.
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公开(公告)号：WO2022232253A1
公开(公告)日：2022-11-03
申请号：PCT/US2022/026514
申请日：2022-04-27
IPC分类号： C12Q1/6883 , A61K39/00
摘要： A Provided herein are methods and compositions for patient selection and therapies targeting TL1A. In particular, provided is a method of treating moderate to severely active Crohn's disease (CD) or ulcerative colitis (UC) in a subject, the method comprising: administering a therapeutically effective amount of an inhibitor of Tumor necrosis factor-like cytokine 1A (TL1A) activity or expression to a subject with moderately to severely active CD or UC that has been determined have a polygenetic risk score (PRS) in the 75th percentile, which is indicative of high fold-change of TL1A expression relative to a cut-off fold-change value. Calculating a PRS comprises providing genomic data comprising one or more genotypes (e.g. rs11221332, rs7134599, rs6062496, rs4246905, rs7468800, rs1569328, rs2284553, rs6062504, and rs7556897) of the subject associated with high TL1A fold-change relative to an index or a control.
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公开(公告)号：WO2022198050A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020954
申请日：2022-03-18
申请人： CEDARS-SINAI MEDICAL CENTER , SLOMKA, Piotr , KILLEKAR, Aditya , CADET, Sebastien , DEY, Damini
发明人： SLOMKA, Piotr , KILLEKAR, Aditya , CADET, Sebastien , DEY, Damini
IPC分类号： G06T7/00
摘要： Convolutional long short-term memory (LSTM) networks are leveraged to segment and/or quantify medical imaging data. A multi-branch architecture makes use of an attention branch and a main branch. The main branch includes a dense block followed by a segmentation head, and is configured to consider a single input slice of the imaging data. This main branch is able to segment larger and easier-to-classify targets. The attention branch, however, makes use of a sequential processor that includes a convolutional LSTM (ConvLSTM) followed by a segmentation head and an attention head. This attention branch is configured to process an input slice and additional adjacent slices. This attention branch is able to segment smaller and more difficult to classify targets.
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公开(公告)号：WO2022140435A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064678
申请日：2021-12-21
发明人： JORDAN, Stanley C. , AMMERMAN, Noriko , VO, Ashley , KIM, Irene , KUMAR, Sanjeev
摘要： The present invention describes method for reducing Delayed Graft Function (DGF) and Ischemia/Reperfusion Injury (IRI) by intra-renal infusion of a C1 esterase inhibitor.
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公开(公告)号：WO2022076657A1
公开(公告)日：2022-04-14
申请号：PCT/US2021/053923
申请日：2021-10-07
发明人： GUPTA, Kapil , VERNON, John , CHOW, Cary , SAWHNEY, Ravi
摘要： Methods and devices for cleaning heads of tubular instruments, such as endoscopes, are disclosed. A cleaning apparatus can include a receiving block for receiving an instrument head. A clamp can be used to secure the tube of the tubular instrument while also establishing a watertight seal. A nozzle assembly underneath the receiving block can include a nozzle that directs a stream of fluid onto the instrument head. The nozzle assembly can be rotatable about an axis of rotation, and optionally slidable along the axis of rotation. Extent of rotation and sliding movement can be limited (e.g., via one or more stops). Through movement of the nozzle assembly, the stream of fluid can be directed into various openings and crevices of the instrument head, thus permitting a quick and easy way to thoroughly clean such instrument heads.
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公开(公告)号：WO2022031606A2
公开(公告)日：2022-02-10
申请号：PCT/US2021/044195
申请日：2021-08-02
发明人： KORONYO, Maya , BLACK, Keith L. , KAVANAUGH, Jack
IPC分类号： A61K31/202 , A61K31/232 , A61K31/27 , A61P25/28 , A61K31/547
摘要： Provided herein are compositions and methods that improve cognition in individuals having or at risk of having Alzheimers disease, including familial Alzheimers disease, early-onset Alzheimers disease, and middle to late stage Alzheimers disease.
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公开(公告)号：WO2021226400A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/031185
申请日：2021-05-06
IPC分类号： A61B17/10
摘要： Disclosed are systems and methods for safely and effectively deploying a hemoclip onto a patient's desired target using a hemoclip system. For instance, disclosed is an catheter that includes a lumen for a hemoclip to pass through. Additionally, disclosed are hemoclips that are configured to be in a compressed position until the hemoclip is deployed out of a catheter where it opens. Then, the hemoclip may be clipped onto the target to encapsulate the desired target within the patient. Once the hemoclip is clamped onto the target, the catheter can move onto the next target for successive deployment and utilization of the hemoclips without manual reload.
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公开(公告)号：WO2021226095A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/030667
申请日：2021-05-04
发明人： CHRISTODOULOU, Anthony , FAN, Zhaoyang , LI, Debiao , HAN, Pei
摘要： A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.
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公开(公告)号：WO2021222849A2
公开(公告)日：2021-11-04
申请号：PCT/US2021/030322
申请日：2021-04-30
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , STRIPP, Barry R. , MULAY, Apoorva , KONDA, Bindu , SHARMA, Arun , SVENDSEN, Clive , ARUMUGASWAMI, Vaithilingaraja , SAREEN, Dhruv , SHAHARUDDIN, Hanan , WANG, Victoria , SANTOS, Roberta S.
发明人： STRIPP, Barry R. , MULAY, Apoorva , KONDA, Bindu , SHARMA, Arun , SVENDSEN, Clive , ARUMUGASWAMI, Vaithilingaraja , SAREEN, Dhruv , SHAHARUDDIN, Hanan , WANG, Victoria , SANTOS, Roberta S.
IPC分类号： A61K35/12 , A61K35/36 , A61K35/545 , C12N15/09 , C12N5/10 , C12N2503/02 , C12N2506/45 , C12N2510/00 , C12N5/0676
摘要： Described herein are particular infection model systems, methods of studying infection, and method of screening compounds in various model systems. Particularly, SARS-CoV-2 is studied in these organ and infection models.
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