Invention Application
WO2016075481A1 FRET MOLECULAR PROBES WITH CLEAVABLE LINKERS FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO
审中-公开
FRET分子探针，用于检测细菌和/或真菌在体外和体内的可清除的链接
- Patent Title: FRET MOLECULAR PROBES WITH CLEAVABLE LINKERS FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO
- Patent Title (中): FRET分子探针，用于检测细菌和/或真菌在体外和体内的可清除的链接
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Application No.: PCT/GB2015/053452Application Date: 2015-11-13
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Publication No.: WO2016075481A1Publication Date: 2016-05-19
- Inventor: BRADLEY, Mark , LILIENKAMPF, Annamaria Helena , AVLONITIS, Nikolaos , ESCOBAR, Marc Vendrell , MCDONALD, Neil Alexander , HASLETT, Christopher , DHALIWAL, Kanwaldeep , WALSH, Timothy Simon
- Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
- Applicant Address: Old College South Bridge, Edinburgh Midlothian EH8 9YL GB
- Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
- Current Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
- Current Assignee Address: Old College South Bridge, Edinburgh Midlothian EH8 9YL GB
- Agency: HGF LIMITED (GLASGOW)
- Priority: GB1420223.8 20141113
- Main IPC: A61K49/00
- IPC: A61K49/00 ; C12Q1/22 ; C12Q1/37 ; G01N33/52
Abstract:
An optical probe is provided comprising a probe element connected to a quencher by a cleavable linker; the probe element comprising a binding moiety, and a fluorophore being substantially fluorescently quenched by the quencher when the probe element is connected to the quencher by the cleavable linker; wherein the probe element is separated from the quencher when the cleavable linker is cleaved. Methods of using the probe are also provided.
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