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1.发明申请MOLECULAR PROBES FOR DETECTING GRAM-NEGATIVE BACTERIA IN VITRO AND IN VIVO 审中-公开用于检测血管和体内血液中阴性细菌的分子探针
公开(公告)号：WO2016075483A1
公开(公告)日：2016-05-19
申请号：PCT/GB2015/053454
申请日：2015-11-13
Inventor： BRADLEY, Mark , LILIENKAMPF, Annamaria Helena , AVLONITIS, Nikolaos , ESCOBAR, Marc Vendrell , MCDONALD, Neil Alexander , HASLETT, Christopher , DHALIWAL, Kanwaldeep , WALSH, Timothy Simon
CPC classification number: A61K49/0021 , A61K49/0056 , C12Q1/04 , G01N33/532
Abstract: A probe is provided comprising a label and a binding moiety, wherein the binding moiety is adapted to bind to gram-negative bacteria, and to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.
Abstract translation: 提供了包含标记和结合部分的探针，其中结合部分适于结合革兰氏阴性细菌，并且基本上不结合动物细胞或革兰氏阳性菌。 还提供了检测目标区域中细菌存在的方法，其允许通常检测细菌，以及确定该细菌是革兰氏阴性还是革兰氏阳性。
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2.发明申请FRET MOLECULAR PROBES WITH CLEAVABLE LINKERS FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO 审中-公开FRET分子探针，用于检测细菌和/或真菌在体外和体内的可清除的链接
公开(公告)号：WO2016075481A1
公开(公告)日：2016-05-19
申请号：PCT/GB2015/053452
申请日：2015-11-13
Inventor： BRADLEY, Mark , LILIENKAMPF, Annamaria Helena , AVLONITIS, Nikolaos , ESCOBAR, Marc Vendrell , MCDONALD, Neil Alexander , HASLETT, Christopher , DHALIWAL, Kanwaldeep , WALSH, Timothy Simon
CPC classification number: A61K49/0019 , A61K49/0056 , C12Q1/37 , G01N33/542 , G01N33/56961 , G01N2333/966
Abstract: An optical probe is provided comprising a probe element connected to a quencher by a cleavable linker; the probe element comprising a binding moiety, and a fluorophore being substantially fluorescently quenched by the quencher when the probe element is connected to the quencher by the cleavable linker; wherein the probe element is separated from the quencher when the cleavable linker is cleaved. Methods of using the probe are also provided.
Abstract translation: 提供光学探针，其包括通过可切割接头连接到猝灭剂的探针元件; 所述探针元件包含结合部分，并且当所述探针元件通过所述可切割接头与所述猝灭剂连接时，所述荧光团基本上被所述猝灭剂荧光淬灭; 其中当切割的接头被切割时，探针元件与猝灭剂分离。 还提供了使用探针的方法。
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3.发明申请FLUORESCENT POLYBRANCHED PROBES FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO 审中-公开用于检测细菌和/或真菌中的细菌和/或真菌的荧光聚合物探针
公开(公告)号：WO2016075484A1
公开(公告)日：2016-05-19
申请号：PCT/GB2015/053455
申请日：2015-11-13
Inventor： BRADLEY, Mark , LILIENKAMPF, Annamaria Helena , AVLONITIS, Nikolaos , ESCOBAR, Marc Vendrell , MCDONALD, Neil Alexander , HASLETT, Christopher , DHALIWAL, Kanwaldeep , WALSH, Timothy Simon
CPC classification number: G01N33/56911 , A61K49/0021 , A61K49/0054 , A61K49/0056 , G01N33/56961 , G01N33/582 , G01N2333/195 , G01N2333/37
Abstract: A probe is provided comprising a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and comprising a fluorophore and a binding moiety. Methods of use of the probe and kits comprising the probe are also provided.
Abstract translation: 提供了包括芯和多个探针元件的探针; 多个探针元件中的每个探针元件从芯延伸并且包含荧光团和结合部分。 还提供了使用探针的方法和包含探针的试剂盒。
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