发明申请
WO2017031249A1 WHOLE-BODY TISSUE STABILIZATION AND SELECTIVE EXTRACTIONS VIA TISSUE-HYDROGEL HYBRIDS FOR HIGH RESOLUTION INTACT CIRCUIT MAPPING AND PHENOTYPING
审中-公开
通过用于高分辨率电路映射和显色的组织 - 水凝胶混合物进行全身组织稳定和选择性提取
- 专利标题： WHOLE-BODY TISSUE STABILIZATION AND SELECTIVE EXTRACTIONS VIA TISSUE-HYDROGEL HYBRIDS FOR HIGH RESOLUTION INTACT CIRCUIT MAPPING AND PHENOTYPING
- 专利标题（中）： 通过用于高分辨率电路映射和显色的组织 - 水凝胶混合物进行全身组织稳定和选择性提取
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申请号： PCT/US2016/047430申请日： 2016-08-17
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公开(公告)号： WO2017031249A1公开(公告)日： 2017-02-23
- 发明人: GRADINARU, Viviana , TREWEEK, Jennifer
- 申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
- 申请人地址： 1200 East California Boulevard M/C 6-32 Pasadena, California 91125 US
- 专利权人： CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人： CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 1200 East California Boulevard M/C 6-32 Pasadena, California 91125 US
- 代理机构： DUKE, Brian T. et al.
- 优先权： US62/205,899 20150817
- 主分类号： G01N21/64
- IPC分类号： G01N21/64 ; G01N3/04 ; G01N33/58 ; G01N33/50 ; C12Q1/68
摘要：
In various embodiments, the present application teaches methods for tissue clearing in which tissues are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches ePACT, which is a protocol for enhanced tissue clearing via expansion. In some embodiments, the present application teaches visualizing a tissue that has been expanded via ePACT.
