发明申请
WO2017176830A1 MOLECULARLY-IMPRINTED-POLYMER COATED CONDUCTIVE NANOPARTICLES FOR COTININE DETECTION, AND ASSOCIATED DEVICES AND METHODS
审中-公开
用于CO检测的分子印迹聚合物涂覆的导电纳米颗粒及相关装置和方法
- 专利标题： MOLECULARLY-IMPRINTED-POLYMER COATED CONDUCTIVE NANOPARTICLES FOR COTININE DETECTION, AND ASSOCIATED DEVICES AND METHODS
- 专利标题（中）： 用于CO检测的分子印迹聚合物涂覆的导电纳米颗粒及相关装置和方法
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申请号： PCT/US2017/026056申请日： 2017-04-05
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公开(公告)号： WO2017176830A1公开(公告)日： 2017-10-12
- 发明人: CHAI, Ziyi , BELBRUNO, Joseph, J.
- 申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , CHAI, Ziyi
- 申请人地址： 11 Rope Ferry Road, Room 6210 Hanover, NH 03755 US
- 专利权人： THE TRUSTEES OF DARTMOUTH COLLEGE,CHAI, Ziyi
- 当前专利权人： THE TRUSTEES OF DARTMOUTH COLLEGE,CHAI, Ziyi
- 当前专利权人地址： 11 Rope Ferry Road, Room 6210 Hanover, NH 03755 US
- 代理机构： DELANEY, Marie J. et al.
- 优先权： US62/318,700 20160405
- 主分类号： B82Y30/00
- IPC分类号： B82Y30/00 ; B82Y15/00 ; G01N33/50 ; G01N33/00 ; G01N27/26 ; G01N27/00 ; G01N27/30
摘要：
A device for detecting cotinine includes (a) a film that includes a plurality of molecularly-imprinted-polymer (MIP) coated conductive nanoparticles having specific affinity for binding with cotinine, and (b) two electrodes in contact with the film for passing electrical current through the film to detect binding with cotinine as a change in electrical conductivity of the film. A MIP coated conductive nanoparticle for detecting cotinine includes (a) a conductive nanoparticle, (b) a silicon dioxide coating formed on the conductive nanoparticle and forming a first shell around the conductive nanoparticle, and (c) an MIP coating formed on the silicon dioxide coating and forming the second shell, wherein the MIP coating includes a polymer molecularly imprinted with cotinine to provide specific affinity for binding of cotinine to the MIP coated conductive nanoparticle such that the cotinine is detectable as a change in electrical conductivity of the MIP coated conductive nanoparticle.
