Invention Application
- Patent Title: RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
- Patent Title (中): 呼吸道合胞病毒抑制剂
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Application No.: PCT/SE2017/050846Application Date: 2017-08-23
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Publication No.: WO2018038667A1Publication Date: 2018-03-01
- Inventor: AYESA, Susana , BYLUND, Johan , ERSMARK, Karolina , SALVADOR ODEN, Lourdes , SEHGELMEBLE, Fernando
- Applicant: MEDIVIR AB
- Applicant Address: Att. Kerstin Ekelöf Box 1086 141 22 Huddinge SE
- Assignee: MEDIVIR AB
- Current Assignee: MEDIVIR AB
- Current Assignee Address: Att. Kerstin Ekelöf Box 1086 141 22 Huddinge SE
- Priority: SE1651152-9 20160825
- Main IPC: C07D471/20
- IPC: C07D471/20 ; A61K31/501 ; A61P31/14 ; C07D237/04 ; C07D401/14 ; C07D487/10
Abstract:
Compounds of Formula (I): wherein W is NR 1A or CR 1B R 1B ; Z is N or CH; R 1A is C 1 -C 3 alkyl, C 1 -C 3 haloalkyl C 3 -C 4 cycloalkyl or phenyl wherein cycloalkyl or phenyl is optionally mono-, di- or tri-substituted with substituents each independently selected from C 1 - C 3 alkyl, halo, amino and C 1 -C 3 alkoxy; the two R 1B together with the carbon atom to which they are attached combine and form C 3 -C 6 cycloalkyl or heterocyclyl, wherein the cycloalkyl is substituent with C(=O)OR 1C , NHC(=O)OR 1C or NHS(=O) 2 R 1C , and the heterocyclyl is substituent with C(=O)R 1C , C(=O)OR 1C , S(=O) 2 R 1C , C(=O)NH 2 or C(=O)NR 1C R 1C' ; n is 0, 1 or 2; n, q, R 1C , R 1C ', R 2 and R 3 are as defined herein, their use as inhibitors of RSV and related aspects.
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