发明申请
WO2018050793A1 PROCESS FOR PREPARING PHOSPHONIUM SALT ESTERS AS BUILDING BLOCKS FOR CAROTENOIDES
审中-公开
用于制备类胡萝卜素块的磷鎓盐酯的方法
- 专利标题： PROCESS FOR PREPARING PHOSPHONIUM SALT ESTERS AS BUILDING BLOCKS FOR CAROTENOIDES
- 专利标题（中）： 用于制备类胡萝卜素块的磷鎓盐酯的方法
-
申请号： PCT/EP2017/073219申请日： 2017-09-15
-
公开(公告)号： WO2018050793A1公开(公告)日： 2018-03-22
- 发明人: SCHAEFER, Bernd , SIEGEL, Wolfgang
- 申请人： BASF SE
- 申请人地址： Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein DE
- 专利权人： BASF SE
- 当前专利权人： BASF SE
- 当前专利权人地址： Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein DE
- 代理机构： POHL, Michael
- 优先权： EP16189282.3 20160916
- 主分类号： C07F9/54
- IPC分类号： C07F9/54 ; C07C403/08 ; C07C403/16 ; C07C403/24
摘要：
The present invention relates to a process for preparing a phosphonium salt ester of the formula (I), wherein R 1 is e.g. hydrogen, C 1 -C 20 -alkyl, C 2 -C 20 -alkenyl, C 4 -C 20 -alkdienyl, C 6 -C 20 -alktrienyl or C 8 -C 20 -alktetraenyl, R 2 is e.g. hydrogen or -NR a R b , wherein R a is e.g. hydrogen, C 1 -C 4 -alkyl, -C(O)-C 1 -C 3 -alkyl, -Boc or -Cbz, R b is e.g. hydrogen or C 1 -C 4 -alkyl, R 3 is e.g. hydrogen, X is CH 2 or C=O, R 4 is phenyl, tert-butyl or tolyl, Y - is a suitable counteranion, the process being characterized in that an alcohol of the formula (IV), is reacted with a carboxylic acid or one of its derivatives of the formula (V), wherein the variables R 1 , R 2 and R 3 are as defined above, and for n = 1 the variable Z is halogen, -OH or -O-C(O)-C 1 -C 4 -alkyl, and for n = 2 the variable Z is O or S, wherein the reaction is carried out in the presence of a tertiary amine and in case a compound of the formula (IV) with Z = -OH is used also in the presence of an activator. The invention further relates to certain phosphonium salt esters of the formula (I).
