Invention Application
WO2018089830A1 EFFICIENT AND SCALABLE SYNTHESES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS THEREOF, ADENYLYL DINUCLEOTIDE CONJUGATES THEREOF, AND NOVEL CRYSTALLINE FORMS THEREOF
审中-公开
烟酰基核苷和降低的烟酰基核糖核苷及其修饰衍生物的有效和可缩合的合成，其磷酸化类似物，其烯丙基DIN核苷酸结合物及其新型结晶形式
- Patent Title: EFFICIENT AND SCALABLE SYNTHESES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS THEREOF, ADENYLYL DINUCLEOTIDE CONJUGATES THEREOF, AND NOVEL CRYSTALLINE FORMS THEREOF
- Patent Title (中): 烟酰基核苷和降低的烟酰基核糖核苷及其修饰衍生物的有效和可缩合的合成，其磷酸化类似物，其烯丙基DIN核苷酸结合物及其新型结晶形式
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Application No.: PCT/US2017/061154Application Date: 2017-11-10
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Publication No.: WO2018089830A1Publication Date: 2018-05-17
- Inventor: MIGAUD, Marie, Eugenie , REDPATH, Philip , CROSSEY, Kerri , CUNNINGHAM, Richard , ERICKSON, Aron , NYGAARD, Richard , STORJOHANN, Amanda
- Applicant: THE QUEEN'S UNIVERSITY OF BELFAST , CHROMADEX INC.
- Applicant Address: University Road Belfast, NI BT7 1NN GB
- Assignee: THE QUEEN'S UNIVERSITY OF BELFAST,CHROMADEX INC.
- Current Assignee: THE QUEEN'S UNIVERSITY OF BELFAST,CHROMADEX INC.
- Current Assignee Address: University Road Belfast, NI BT7 1NN GB
- Agency: SUSSMAN, Adam, D. et al.
- Priority: US62/420,737 20161111; US15/809,731 20171110; US15/809,753 20171110; US62/558,073 20170913
- Main IPC: A61K31/455
- IPC: A61K31/455 ; A61K31/706 ; C07H1/00 ; C07H19/048
Abstract:
The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X", Z 1 , Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6, , R 7 , and R 8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Information query
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