公开(公告)号：WO2018089830A1

公开(公告)日：2018-05-17

申请号：PCT/US2017/061154

申请日：2017-11-10

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  CHROMADEX INC.

Inventor： MIGAUD, Marie, Eugenie ,  REDPATH, Philip ,  CROSSEY, Kerri ,  CUNNINGHAM, Richard ,  ERICKSON, Aron ,  NYGAARD, Richard ,  STORJOHANN, Amanda

IPC: A61K31/455 ,  A61K31/706 ,  C07H1/00 ,  C07H19/048

Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X", Z 1 , Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6, , R 7 , and R 8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

Abstract translation: 本公开提供了制备烟酰基核糖核苷化合物或式（I）的衍生物的方法：其中X 1，Z 1，Z 2，Z 3， n，R 1，R 2，R 3，R 4，R 5，R 5，R 4，R 4，R 5， 本文描述了R 6，R 7，R 8和R 8，其还原类似物，修饰的衍生物 其磷酸化类似物和腺苷酸二核苷酸缀合物，或其盐，溶剂化物或前药; 及其新颖的结晶形式。

公开(公告)号：WO2017161165A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022779

申请日：2017-03-16

Applicant: CHROMADEX INC. ,  THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： MIGAUD, Marie, Eugenie ,  REDPATH, Philip ,  CROSSEY, Kerri ,  CUNNINGHAM, Richard ,  DELLINGER, Ryan ,  RHONEMUS, Troy ,  VENKATARAMAN, Sylesh ,  NETTLES, Brian

IPC: A01N43/40 ,  A61K31/44

Abstract: The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X - , Z 1 Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.

Abstract translation: 本公开提供了烟酸酯/烟酰胺核糖核苷化合物或式（I）的衍生物：其中X 1，Z 1 Z Z 2 n，R 1，R 2，R 3，R 4，R 5，R 4，R 4，R 4，R 4， 本文描述了R 5，R 6，R 7和R 8，它们的还原类似物，以及用于 准备。

公开(公告)号：WO2016149395A1

公开(公告)日：2016-09-22

申请号：PCT/US2016/022682

申请日：2016-03-16

Applicant: CHROMADEX INC. ,  THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： DELLINGER, Ryan ,  MIGAUD, Marie, Eugenie ,  REDPATH, Philip ,  RHONEMUS, Troy ,  CUNNINGHAM, Richard

IPC: C07H19/048 ,  A61K31/706

CPC classification number: C07H19/048 ,  A61K8/675 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/007 ,  A61Q19/08

Abstract: Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2', 3', 5'-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.

Abstract translation: 烟碱苷（NAR）衍生物，烟酰胺核苷（NR）和还原的NAR和NR，包括1-（2'，3'，5'-三乙酰基-β-D-呋喃核糖基）-1,4-二氢烟酸 提供了含有相同和/或还原的衍生物形式的包括1-（2'，3'，5'-三乙酰基-β-D-呋喃核糖基）-1,4-烟酰胺（2）的烟酰胺核苷的组合物 用于护理皮肤和皮肤状况的治疗。 在一些实施方案中，本发明涉及含有一种或多种NR，NAR，NRH或NARH衍生物或其前药或盐的药物组合物和化妆品组合物。 在进一步的实施方案中，本发明涉及使用一种或多种NR，NAR，NRH或NARH衍生物或其前药，溶剂合物或其盐来促进细胞中烟酰胺腺嘌呤二核苷酸（NAD +）的细胞内水平的增加的方法，以及 用于改善细胞和组织存活的组织以及整个细胞和组织的健康。