- 专利标题： HETEROCYCLIC COMPOUNDS DERIVATIVES AS PD-L1 INTERNALIZATION INDUCERS
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申请号： PCT/US2017/067946申请日： 2017-12-21
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公开(公告)号： WO2018119263A1公开(公告)日： 2018-06-28
- 发明人: LU, Liang , ZHANG, Fenglei , LI, Jingwei , WANG, Haisheng , XIAO, Kaijiong , WU, Liangxing , QIAN, Ding-Quan , LAJKIEWICZ, Neil , KONKOL, Leah , LI, Zhenwu , XU, Meizhong , YAO, Wenqing
- 申请人： INCYTE CORPORATION , LU, Liang , ZHANG, Fenglei , LI, Jingwei , WANG, Haisheng , XIAO, Kaijiong
- 申请人地址： 1801 Augustine Cut-Off Wilmington, Delaware 19803 US
- 专利权人： INCYTE CORPORATION,LU, Liang,ZHANG, Fenglei,LI, Jingwei,WANG, Haisheng,XIAO, Kaijiong
- 当前专利权人： INCYTE CORPORATION,LU, Liang,ZHANG, Fenglei,LI, Jingwei,WANG, Haisheng,XIAO, Kaijiong
- 当前专利权人地址： 1801 Augustine Cut-Off Wilmington, Delaware 19803 US
- 代理机构： KARNAS, Elizabeth T. et al.
- 优先权： US62/437,998 20161222; US62/487,365 20170419
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61P35/00 ; A61P37/00 ; A61K31/437 ; C07D213/74 ; C07D311/04 ; C07D217/02 ; C07D217/04 ; C07D401/06 ; C07D401/12 ; C07D403/06 ; C07D487/04 ; C07D495/04 ; C07D209/44 ; C07D211/60 ; C07D213/38 ; C07C215/28 ; C07D471/10 ; C07D209/14 ; C07D513/04 ; C07D295/02 ; C07D211/56 ; C07D211/58
摘要：
Disclosed are compounds of Formula (I'), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
