发明申请
- 专利标题： CHEMICAL COMPOUNDS
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申请号： PCT/GB2018/050623申请日： 2018-03-12
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公开(公告)号： WO2018167468A1公开(公告)日： 2018-09-20
- 发明人: HARRISON, David , WATT, Alan Paul , BOUTARD, Nicolas , FABRITIUS, Charles-Henry , GALEZOWSKI, Michal , KOWALCZYK, Piotr , LEVENETS, Oleksandr , WOYCIECHOWSKI, Jakub
- 申请人： NODTHERA LIMITED
- 申请人地址： 137a George Street Edinburgh EH2 4JY GB
- 专利权人： NODTHERA LIMITED
- 当前专利权人： NODTHERA LIMITED
- 当前专利权人地址： 137a George Street Edinburgh EH2 4JY GB
- 代理机构： STRATAGEM IPM LIMITED
- 优先权： GB1703979.3 20170313
- 主分类号： C07D231/12
- IPC分类号： C07D231/12 ; C07D231/14 ; C07D233/10 ; C07D233/96 ; C07D237/08 ; C07D239/26 ; C07D261/08 ; C07D271/10 ; C07C13/00 ; C07D213/06 ; A61K31/64 ; A61P35/00
摘要：
The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.
