摘要:
The present disclosure relates to novel compounds useful as inhibitors of ATR kinase, as well as pharmaceutical compositions comprising these compounds and methods of treatment by administration of these compounds or the pharmaceutical compositions.
摘要:
The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.
摘要:
Die vorliegende Erfindung beschreibt Verbindungen, welche zur Herstellung von Funktionsschichten elektronischer Vorrichtungen einsetzbar sind, insbesondere zur Verwendung in elektronische Vorrichtungen. Die Erfindung betrifft ferner ein Verfahren zur Herstellung der erfindungsgemäßen Verbindungen sowie elektronische Vorrichtungen, enthaltend diese.
摘要:
The present patent application relates to compounds of formula (1) wherein Y and Z are independently O, N, P; R, R 1 , R 2 , R 3 , where present, are independently H, optionally substituted C 1 -C 12 alkyl, O, or R and R 1 and/or R 2 and R 3 form, together with the atom Y and/or Z to which they are attached, a 3-14 membered ring, optionally containing one or more additional heteroatoms selected from O, N, and S, optionally substituted, compositions comprising such compounds and the medical use of such compounds.
摘要:
The present invention relates to an organic electronic device comprising, between an anode and a cathode, at least one layer selected from an electron injection layer, an electron transport layer or an electron generation layer, the layer comprising at least one compound of the following Formula (I), wherein the compound of Formula (I) comprises one or more moieties -(A) a -L and the remaining positions marked with "*" are hydrogen or substituents independently selected from the group consisting of deuterium, fluorine, RF, C 1 -C 20 linear alkyl, C 3 -C 20 branched alkyl, C 1 -C 12 linear fluorinated alkyl, CN, RCN, C 6 -C 20 aryl, C 2 -C 20 heteroaryl, (P=O)R 2 ; wherein each R is independently selected from C 1 -C 20 linear alkyl, C 1 -C 20 alkoxy, C 1 -C 20 thioalkyl, C 3 -C 20 branched alkyl, C 3 -C 20 cyclic alkyl, C 3 -C 20 branched alkoxy, C 3 -C 20 cyclic alkoxy, C 3 -C 20 branched thioalkyl, C 3 -C 20 cyclic thioalkyl, C 6 -C 20 aryl and C 2 -C 20 heteroaryl; A is selected from substituted or unsubstituted C 6 -C 24 aryl or C 2 -C 20 heteroaryl; wherein in case that A is substituted, the respective substituents are independently selected from the group consisting of deuterium, fluorine, C 1 -C 20 linear alkyl, C 3 -C 20 branched alkyl, linear fluorinated C 1 -C 12 alkyl, CN, C 6 -C 20 aryl, and C 2 -C 20 heteroaryl; L is selected from substituted or unsubstituted C 2 -C 42 heteroaryl, substituted or unsubstituted C 6 -C 24 aryl or a polar group selected from (formula (aa)), (formula (bb)) and (formula (cc)), wherein substituents, if present in the respective group L are independently selected from the group consisting of deuterium, fluorine, C 1 -C 20 linear alkyl, C 3 -C 20 branched alkyl, C 3 -C 20 cyclic alkyl, C 1 -C 20 linear alkoxy, C 3 -C 20 branched alkoxy, C 1 -C 12 linear fluorinated alkyl, C 1 -C 12 linear fluorinated alkoxy, C 3 -C 12 branched fluorinated cyclic alkyl, C 3 -C 12 fluorinated cyclic alkyl, C 3 -C 12 fluorinated cycle alkoxy, CN, RCN, C 6 -C 20 aryl, C 2 -C 20 heteroaryl, OR, SR, (C=O)R, (C=O)NR 2 , SiR 3 , (S=O)R (S=O) 2 R, (Ρ=O)R 2 ; wherein each R independenfly selected from C 1 -C 20 linear alkyl, C 1 -C 20 alkoxy, C 1 -C 20 thioalkyl, C 3 -C 20 branched alkyl, C 3 -C 20 cyclic alkyl, C 3 -C 20 branched alkoxy, C 3 -C 20 cyclic alkoxy, C 3 -C 20 branched thioalkyl, C 3 -C 20 cyclic thioalkyl, C 6 -C 20 aryl and C 2 -C 20 heteroaryl, and "a" is an integer from o to 2, respective compounds as well as display and lightning devices comprising the same.
摘要:
The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.
摘要:
본 발명은 전자 주입 및 수송능, 발광능 등이 우수한 신규 유기 화합물 및 이를 포함하는 유기 전계 발광 소자에 대한 것으로서, 상기 유기 화합물이 유기 전계 발광 소자의 유기물층에 사용됨에 따라, 소자의 열적 안정성, 발광효율, 구동 전압, 수명 등을 향상시킬 수 있다.
摘要:
The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.