- 专利标题： OXADIAZOLE LINKERS AND USE THEREOF
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申请号： PCT/CN2018/089767申请日： 2018-06-04
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公开(公告)号： WO2019011078A1公开(公告)日： 2019-01-17
- 发明人: HAN, Nianhe , AN, Deqiang , ZENG, Di , WANG, Baoxiang , LI, Huali , CHEN, Hang , YANG, Chun
- 申请人： NEWBIO THERAPEUTICS, INC.
- 申请人地址： Suite 101, Bldg. 9, 1011 Halei Road Pudong New District Shanghai 201203 CN
- 专利权人： NEWBIO THERAPEUTICS, INC.
- 当前专利权人： NEWBIO THERAPEUTICS, INC.
- 当前专利权人地址： Suite 101, Bldg. 9, 1011 Halei Road Pudong New District Shanghai 201203 CN
- 代理机构： GE CHENG & CO.LTD.
- 优先权： CN201710556847.1 20170710
- 主分类号： C07D271/10
- IPC分类号： C07D271/10 ; C07D271/113 ; A61P37/00 ; A61P35/00 ; A61P29/00 ; A61K31/10 ; A61K31/4245
摘要：
Provided is oxadiazole linkers and use thereof, more specifically to the compounds represented by formulas (I), (II), and (III), and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula (I), (II), and (III) is the same as that in the description.
