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公开(公告)号：WO2016192527A1
公开(公告)日：2016-12-08
申请号：PCT/CN2016/082286
申请日：2016-05-17
发明人： HAN, Nianhe , AN, Deqiang , ZHU, Peng , HOU, Chengyu , YANG, Hang , JIAN, Li , YANG, Chun
CPC分类号： C07K5/06034 , A61K38/00 , A61K47/6817 , A61K47/6851 , C07K7/02 , C07K16/32 , C07K2317/73
摘要： Derivatives of dolastatin 10 and uses thereof, the structures of which are shown as formula I, II, III and IV are provided.
摘要翻译： 提供了多拉司他汀10的衍生物及其用途，其结构如式I，II，III和IV所示。
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公开(公告)号：WO2019011078A1
公开(公告)日：2019-01-17
申请号：PCT/CN2018/089767
申请日：2018-06-04
发明人： HAN, Nianhe , AN, Deqiang , ZENG, Di , WANG, Baoxiang , LI, Huali , CHEN, Hang , YANG, Chun
IPC分类号： C07D271/10 , C07D271/113 , A61P37/00 , A61P35/00 , A61P29/00 , A61K31/10 , A61K31/4245
CPC分类号： C07D271/113 , A61K47/68 , A61K47/6817 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02
摘要： Provided is oxadiazole linkers and use thereof, more specifically to the compounds represented by formulas (I), (II), and (III), and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula (I), (II), and (III) is the same as that in the description.
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公开(公告)号：WO2016192528A1
公开(公告)日：2016-12-08
申请号：PCT/CN2016/082287
申请日：2016-05-17
发明人： HAN, Nianhe , AN, Deqiang , ZENG, Di , WANG, Baoxiang , YANG, Hang , JIAN, Li , YANG, Chun
IPC分类号： A61K47/48 , A61K39/395 , A61K45/00 , C07D207/448 , C07D207/452 , A61P35/00 , A61P37/02 , A61P29/00
CPC分类号： A61K47/6889 , A61K47/6803 , C07D207/452 , C07K16/32 , C07K2317/24
摘要： A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L– (T–A–D) n Ⅰ wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.
摘要翻译： 公开了一种三马来酰亚胺接头及其用途。 三马来酰亚胺接头可用于制备如式I所示的抗体 - 药物结合物：L-（T-A-D）nⅠ其中L为抗体，抗体片段或蛋白质; T是三马来酰亚胺接头; A是可切割的连接基团或不可裂解的连接体; D是一种药物 n为1〜8的整数。
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公开(公告)号：WO2019033773A1
公开(公告)日：2019-02-21
申请号：PCT/CN2018/083515
申请日：2018-04-18
发明人： AN, Deqiang , HAN, Nianhe , ZHU, Peng , ZENG, Di , WANG, Baoxiang , LI, Huali , YANG, Chun
摘要： The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.
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