- 专利标题： CELLS EXPRESSING ANTIBODIES AND METHODS OF TREATMENT USING THE SAME
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申请号： PCT/US2018/059490申请日： 2018-11-06
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公开(公告)号： WO2019090355A1公开(公告)日： 2019-05-09
- 发明人: CRUZ, Conrad Russell Y. , POWELL, Allison Bonasera , BOLLARD, Catherine Mary , JONES, Richard Bradley
- 申请人： CHILDREN'S NATIONAL MEDICAL CENTER , THE GEORGE WASHINGTON UNIVERSITY
- 申请人地址： 111 Michigan Avenue NW Washington, DC 20010 US
- 专利权人： CHILDREN'S NATIONAL MEDICAL CENTER,THE GEORGE WASHINGTON UNIVERSITY
- 当前专利权人： CHILDREN'S NATIONAL MEDICAL CENTER,THE GEORGE WASHINGTON UNIVERSITY
- 当前专利权人地址： 111 Michigan Avenue NW Washington, DC 20010 US
- 代理机构： ZURAWSKI, John A. et al.
- 优先权： US62/582,292 20171106
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07K14/705 ; C07K14/71 ; C07K14/715 ; C12N5/00
摘要：
Genetic constructs, compositions and methods related to generating cellular products that will be used for T-cell- and NK cell -based immunotherapy of refractory solid tumors, hematologic malignancies, and brain tumors with a strong immunosuppressive component are provided. The cells are manufactured to target one or a plurality of hyperproliferative cells, made resistant to the immunosuppressive environment, and modified to secrete antibodies that both neutralize and eliminate essential components of the hyperproliferative cell.
