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公开(公告)号：WO2022261317A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/032829
申请日：2022-06-09
发明人： COLSON, Cindy
IPC分类号： A61B5/00
摘要： A method for determining a burn percentage of a patient, including presenting, via processing circuitry, an image of at least one segment of a body, receiving, via the processing circuitry, a burn indication representing areas within the at least one segment of the body that have sustained a burn, determining, via the processing circuitry, a burned percentage of the at least one segment of the body based on the burn indication, determining, via the processing circuitry, a surface area of the at least one segment of the body based on an age of the patient and a weight of the patient, and determining, via the processing circuitry, the burn percentage of the patient based on the burned percentage of the at least one segment of the body and the surface area of the at least one segment of the body.
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公开(公告)号：WO2022212528A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/022578
申请日：2022-03-30
发明人： SONG, Xiaoyan , SHERMAN, Jules , SHAH, Rahul K.
摘要： The present disclosure relates to an isolation gown. In particular, the present disclosure relates to an isolation gown, comprising a garment body including opening running a length of the garment body and terminating at a neck opening, the garment body having a first side and a second side and being configured to permit a wearer to don the medical gown, sleeves extending distally from the garment body, and one or more restraining mechanisms configured to secure the garment body, the sleeves, or a combination thereof, to a body of the wearer, wherein the one or more restraining mechanisms including an actuatable portion utilizing friction to allow the neck opening of the garment body to be contracted to a size of a neck of the wearer, and expanded to be larger than a shoulder width of the wearer.
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公开(公告)号：WO2022006058A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/039537
申请日：2021-06-29
发明人： JAISWAL, Jyoti, K. , DEFOUR, Aurelia , BITTEL, Daniel , GOUTAM, Chandra , SREETAMA, Sen, Chandra
IPC分类号： A61K48/00 , C12N9/22 , C12N15/09 , C12N15/10 , C12N15/113 , C12N15/55 , C12N15/86 , C12N2750/14143 , C12N2830/008 , C12N9/14
摘要： Compositions and methods for the treatment of muscular dystrophies are provided.
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公开(公告)号：WO2021243303A1
公开(公告)日：2021-12-02
申请号：PCT/US2021/035018
申请日：2021-05-28
发明人： CHEN, Yi-Wen
摘要： Disclosed are compositions and methods for the diagnosis of Facioscapulohumeral muscular dystrophy (FSHD) using nanopore sequencing and CRISPR/Cas9 enrichment of D4Z4 containing sequences to determine the number of repeats in a D4Z repeat region and methyiation of the nucleotide bases in this region.
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公开(公告)号：WO2021243295A2
公开(公告)日：2021-12-02
申请号：PCT/US2021/035008
申请日：2021-05-28
IPC分类号： A61K39/00 , C12N5/00 , A61K2039/5156 , A61K2039/5158 , A61K2039/53 , A61K39/001189
摘要： The invention pertains to a method for treating a cancer which expresses PRAME using T cells which recognize specific peptide epitopes of PRAME, to a method for producing T cells that target cancer cells expressing PRAME, the peptide epitopes of PRAME themselves and to compositions and methods of treatment using these peptides.
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6.发明申请
公开(公告)号：WO2021163466A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/017838
申请日：2021-02-12
发明人： LIU, Yang , WANG, Yin , LIU, Yan , BAILEY, Christopher
摘要： The present invention relates to treating TP53-mutated AML using a Hypoxia-Inducible Factor (HIF inhibitor). The invention further relates to a new HIF inhibitor formulation with longer half-life and significantly improved therapeutic effect for TP53-mutated AML.
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公开(公告)号：WO2019222762A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/033186
申请日：2019-05-20
摘要： The present disclosure provides for isolated and processed cell therapeutic compositions and Methods of using those compositions for the treatment of a patient undergoing a hematopoietic stem cell transplant (HSCT). In some embodiments, the disclosure provides for methods of making these cells by exposing the isolated T cell populations to one or more tumor antigens.
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公开(公告)号：WO2019210282A2
公开(公告)日：2019-10-31
申请号：PCT/US2019/029505
申请日：2019-04-26
发明人： HANLEY, Patrick , KELLER, Michael
IPC分类号： A61K39/04
摘要： The present disclosure relates, at least in part, to mycobacterial polynucleotides and polypeptides, to fragments or variants thereof, to cells comprising the mycobacterial polynucleotides and polypeptides, to cells comprising the mycobacterial polynucleotides and polypeptides, that are engineered to expand T-cells ex vivo, and to methods of use thereof.
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公开(公告)号：WO2019090355A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/059490
申请日：2018-11-06
发明人： CRUZ, Conrad Russell Y. , POWELL, Allison Bonasera , BOLLARD, Catherine Mary , JONES, Richard Bradley
IPC分类号： A61K48/00 , C07K14/705 , C07K14/71 , C07K14/715 , C12N5/00
摘要： Genetic constructs, compositions and methods related to generating cellular products that will be used for T-cell- and NK cell -based immunotherapy of refractory solid tumors, hematologic malignancies, and brain tumors with a strong immunosuppressive component are provided. The cells are manufactured to target one or a plurality of hyperproliferative cells, made resistant to the immunosuppressive environment, and modified to secrete antibodies that both neutralize and eliminate essential components of the hyperproliferative cell.
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公开(公告)号：WO2019060432A3
公开(公告)日：2019-03-28
申请号：PCT/US2018/051776
申请日：2018-09-19
申请人： CHILDREN'S NATIONAL MEDICAL CENTER , THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , ECHIGOYA, Yusuke
IPC分类号： A61K31/7105 , A61K31/711 , A61K47/55 , A61K47/62 , A61K9/127 , C12N15/11 , C12N15/113
摘要： The disclosure relates to compositions comprising a nucleotide sequence having two domains: a locked nucleic acid (LNA) domain and a DNA gap domain, wherein nucleotide sequence binds to an endogenous DUX4 mRNA sequence disrupts DUX4 expression.
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