- 专利标题： ENGINEERED HERPES SIMPLEX VIRUS-1 (HSV-1) VECTORS AND USES THEREOF
-
申请号： PCT/US2020/013432申请日： 2020-01-14
-
公开(公告)号： WO2020185298A1公开(公告)日： 2020-09-17
- 发明人: WEISS, Ron , HOTTELET, Foley, Maria , HUH, Jin , JONES, Ross, D.
- 申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 申请人地址： 77 Massachusetts Avenue Cambridge, MA 02139 US
- 专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 77 Massachusetts Avenue Cambridge, MA 02139 US
- 代理机构： GE, Lingyin et al.
- 优先权： US62/818,464 20190314
- 主分类号： C12N15/869
- IPC分类号： C12N15/869 ; C12N5/10 ; A61K35/763 ; A61K39/245
摘要：
Provided herein are engineered HSV-1 vectors comprising a modified HSV-1 genome. The engineered HSV-1 vectors can be used to deliver genetic circuits (e.g., up to 100 kb) to cells in vitro or in vivo . Methods of treating or diagnosing a disease (e.g., cancer) using the engineered HSV-1 vectors described herein are also provided.
公开/授权文献
IPC分类:
