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公开(公告)号：WO2023091730A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050509
申请日：2022-11-19
申请人： GEORGIA TECH RESEARCH CORPORATION , SYRACUSE UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RAKHA, Tarek , VELIPASALAR, Senem , FERNANDEZ, John , BAYOMI, Norhan
IPC分类号： G06T7/00
摘要： Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration / exfiltration) in a processing pipeline.
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公开(公告)号：WO2023086760A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/079367
申请日：2022-11-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
IPC分类号： G01N23/20025 , B01L3/14 , G01N1/12 , G01N21/09 , G01N21/31
摘要： A system for determining atomic structure and dynamics of salt under certain temperatures as a function of temperature above and below salt melting, contains a quartz tube containing a first end and a second end, and a graphite rod that is located within the quartz tube. The graphite rod contains a hollow center that extends from a top portion of the rod to a location prior to a bottom of the rod, wherein the bottom portion of the rod is enclosed. A sample of salt is located within the hollow center of the graphite rod. A filling material having the characteristics of not reacting to the graphite rod and not changing state with heating of the salt to a melting point of the salt, and wherein the filling material is positioned beneath the graphite rod between the second end of the quartz tube and the bottom of the graphite rod.
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3.发明申请
公开(公告)号：WO2023081467A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/049136
申请日：2022-11-07
IPC分类号： B29C64/124 , B33Y70/10
摘要： Systems, methods, and compositions for using Interfacial Photopolymerization (IPP) for high-resolution digital processing of polymers are disclosed. In IPP, a polymer film can be formed at an interface between two liquids, each containing a species involved in a polymerization reaction. The two liquids can include a photoinitiator and a monomer that are immiscible and/or reactive such that the film can form at the interface. The polymerization reaction can be controlled by a LED light source, which is focused at a reaction zone located at or near the liquid-liquid interface. The resulting polymer results in a high-resolution, high-throughput AM of thermoplastic polymers that enables on-demand production of objects that exhibit exceptional dimensional quality, mechanical properties, and recyclability characteristics.
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公开(公告)号：WO2023069972A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/078337
申请日：2022-10-19
摘要： Genome editing tools for use in systems designed to deliver large genetic elements are disclosed herein. A genome editing system is described, which includes i) an R2 element enzyme or other non-LTR site specific retrotransposon element and ii) a payload RNA, wherein the payload RNA comprises an insertion region and optionally one or more of a 5' homology region, a 3' homology region, and a protein binding element, wherein the insertion region comprises a template for a small or large nucleic acid insertion into the genome, and wherein the R2 element enzyme or other non-LTR site specific retrotransposon element comprises a targeting domain, a reverse transcriptase domain, and a nickase domain. Also disclosed are cells edited using such a genome editing system, methods for editing a genome, and compositions comprising cells edited with this genomic editing system.
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公开(公告)号：WO2023059952A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/074568
申请日：2022-08-05
发明人： CATANIA, Chelsea , FURST, Ariel , FAN, Gang , WASUWANICH, Pris
IPC分类号： A61K9/54 , A61K35/742 , C12N1/20 , A23L33/135 , A61K47/52 , A61K47/6903 , A61K9/0053 , C12N1/00 , C12N1/04 , C12N3/00
摘要： Prokaryotic cells having a metal-phenolic network coating are disclosed, as are compositions including such cells, methods for their use, and methods for producing such cells.
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公开(公告)号：WO2023049177A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/044245
申请日：2022-09-21
摘要： The present description provides methods, assays and reagents for linearly expanding a peptide. The methods and/or linear expanded peptide described herein have several uses such as, but not limited to, peptide (protein) sequencing, high-resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.
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公开(公告)号：WO2023038939A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/042710
申请日：2022-09-07
发明人： GONG, Xun , RENEGAR, Nicholas , LEVI, Retsef , STRANO, Michael
摘要： Computer program products, computer systems, and computer- implemented methods for making and using computational models for prediction of molecular recognition (MR) between a nanomaterial (NM) MR binder and an analyte. Methods for making a computational model involve selecting a candidate NM MR binder and conducting a physical test to determine whether MR occurs between the candidate NM MR binder and an analyte, and correlating features of the candidate NM MR binder with an experimental result obtained from the physical test to produce predictive information for the computational model. Methods for using the computational model involve receiving features of an untested candidate NM MR binder and analyzing the features to produce a prediction score that represents an expected experimental result of a physical test of the untested candidate MR binder and associating the prediction score with the untested candidate MR binder. The MR binder is a corona phase complex made from DNA adsorbed on a single wall carbon nanotube (SWCNT). The computational models include convolutional neural networks (CNN) and gradient boosted decision trees (GBDT).
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公开(公告)号：WO2023003840A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/037537
申请日：2022-07-19
发明人： KIM, Sang-Gook , KIM, Jeehwan
摘要： Resonators comprising a single-crystalline semiconductor, and related systems and methods, are generally described.
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公开(公告)号：WO2023278598A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035549
申请日：2022-06-29
IPC分类号： A61P25/28 , A61P25/14 , A61P21/00 , C12N15/113
摘要： An ALS treatment method includes administering to an ALS patient an inhibitor for a target A or a promoter for a target B. The target A is one or more genes selected from the genes in Table 1-1 or a protein encoded by the gene, and the inhibitor for the target A is a substance that inhibits expression of the gene, or a substance that inhibits a function of the protein encoded by the gene. The target B is one or more genes selected from the genes in Table 1-2 or a protein encoded by the gene, and the promoter for the target B is a substance that promotes the expression of the gene, or a substance that promotes a function of the protein encoded by the gene.
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公开(公告)号：WO2022261318A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/032831
申请日：2022-06-09
发明人： BANAL, James L. , BERLEANT, Joseph , LEISERSON, Charles E. , SCHARDL, Tao Benjamin , BATHE, Mark
IPC分类号： C12Q1/6806
摘要： Disclosed are compositions and methods relating to sequence-controlled storage objected. The disclosed sequence-controlled storage objects can include (a) one or more different sequence-controlled polymers, and (b) a plurality of different feature tags. The sequence-controlled storage object can include (a) one or more different sequence-controlled polymers, and (b) a plurality of different digit tags. Also disclosed are methods of storing desired sequence-controlled polymers as a sequence-controlled storage object, comprising assembling a sequence-controlled storage object from (i) one or more different sequence-controlled polymers, (ii) a plurality of different feature tags, and (iii) optionally one or more encapsulating agents. Also disclosed are methods of automating the assembly of a sequence-controlled storage object comprising using a device with flow.
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