发明申请
- 专利标题： APOLIPOPROTEIN E (APOE) IRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
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申请号： PCT/US2021/029081申请日： 2021-04-26
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公开(公告)号： WO2021222065A8公开(公告)日： 2021-11-04
- 发明人: BOSTWICK, Bret, Lee , PENG, Haiyan , MCININCH, James, D. , CASTORENO, Adam , SCHLEGEL, Mark, K.
- 申请人： ALNYLAM PHARMACEUTICALS, INC. , BOSTWICK, Bret, Lee , PENG, Haiyan , MCININCH, James, D. , CASTORENO, Adam , SCHLEGEL, Mark, K.
- 申请人地址： 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.,BOSTWICK, Bret, Lee,PENG, Haiyan,MCININCH, James, D.,CASTORENO, Adam,SCHLEGEL, Mark, K.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.,BOSTWICK, Bret, Lee,PENG, Haiyan,MCININCH, James, D.,CASTORENO, Adam,SCHLEGEL, Mark, K.
- 当前专利权人地址： 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street; 675 West Kendall Street
- 代理机构： ZACHARAKIS, Maria Laccotripe et al.
- 优先权： US63/015,867 2020-04-27
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/713 ; C07H21/00 ; A61P25/28 ; C12N2310/14 ; C12N2310/315 ; C12N2310/344 ; C12N2310/351 ; C12N2310/3515 ; C12N2320/31 ; C12N2320/34
摘要：
The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an APOE gene, as well as methods of inhibiting expression of an APOE gene and methods of treating subjects having an APOE-associated neurodegenerative disease or disorder, e.g., Alzheimer's disease and Parkinson's disease, using such dsRNAi agents and compositions.
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