公开(公告)号：WO2021222065A8

公开(公告)日：2021-11-04

申请号：PCT/US2021/029081

申请日：2021-04-26

Applicant: ALNYLAM PHARMACEUTICALS, INC. ,  BOSTWICK, Bret, Lee ,  PENG, Haiyan ,  MCININCH, James, D. ,  CASTORENO, Adam ,  SCHLEGEL, Mark, K.

Inventor： BOSTWICK, Bret, Lee ,  PENG, Haiyan ,  MCININCH, James, D. ,  CASTORENO, Adam ,  SCHLEGEL, Mark, K.

IPC: C12N15/113 ,  A61K31/713 ,  C07H21/00 ,  A61P25/28 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/344 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/31 ,  C12N2320/34

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an APOE gene, as well as methods of inhibiting expression of an APOE gene and methods of treating subjects having an APOE-associated neurodegenerative disease or disorder, e.g., Alzheimer's disease and Parkinson's disease, using such dsRNAi agents and compositions.

公开(公告)号：WO2021222065A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/029081

申请日：2021-04-26

Applicant: ALNYLAM PHARMACEUTICALS, INC. ,  BOSTWICK, Bret, Lee ,  PENG, Haiyan ,  MCININCH, James, D. ,  CASTORENO, Adam ,  SCHLEGEL, Mark, K.

Inventor： BOSTWICK, Bret, Lee ,  PENG, Haiyan ,  MCININCH, James, D. ,  CASTORENO, Adam ,  SCHLEGEL, Mark, K.

IPC: C12N15/113 ,  A61K31/713 ,  C07H21/00 ,  A61P25/28

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an APOE gene, as well as methods of inhibiting expression of an APOE gene and methods of treating subjects having an APOE-associated neurodegenerative disease or disorder, e.g., Alzheimer's disease and Parkinson's disease, using such dsRNAi agents and compositions.