RECOMBINANT CD40 BINDING PROTEINS AND THEIR USE
摘要:
The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for CD40. In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for activating CD40 in cells expressing CD40, e.g., tumor-localized B-cells, and for treating or diagnosing diseases, such as cancer, in a mammal, including a human.
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