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31 条记录 (耗时 0.014 秒)

    RECOMBINANT CD40 BINDING PROTEINS AND THEIR USE
    1.
    发明申请
    RECOMBINANT CD40 BINDING PROTEINS AND THEIR USE 审中-公开

    公开(公告)号：WO2021229076A1

    公开(公告)日：2021-11-18

    申请号：PCT/EP2021/062874

    申请日：2021-05-14

    申请人： MOLECULAR PARTNERS AG

    发明人： CALABRO, Valérie Perrine ,  RIGAMONTI, Nicolo ,  DOMKE, Clara ,  SCHLEGEL, Anja Christina

    IPC分类号： C07K14/47 ,  C07K14/705

    摘要： The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for CD40. In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for activating CD40 in cells expressing CD40, e.g., tumor-localized B-cells, and for treating or diagnosing diseases, such as cancer, in a mammal, including a human.

    DESIGNED ANKYRIN REPEAT DOMAINS WITH BINDING SPECIFICITY FOR SERUM ALBUMIN
    4.
    发明申请
    DESIGNED ANKYRIN REPEAT DOMAINS WITH BINDING SPECIFICITY FOR SERUM ALBUMIN 审中-公开
    设计用于血清白蛋白的具有结合特异性的ANKYRIN重复域

    公开(公告)号：WO2016156596A1

    公开(公告)日：2016-10-06

    申请号：PCT/EP2016/057272

    申请日：2016-04-01

    申请人： MOLECULAR PARTNERS AG

    发明人： BAKKER, Talitha ,  STUMPP, Michael T. ,  BINZ, Hans Kaspar ,  PHILLIPS, Douglas ,  DOLADO, Ignacio ,  FORRER, Patrik ,  MERZ, Frieder W. ,  SONDEREGGER, Ivo ,  STEINER, Daniel ,  GULOTTI-GEORGIEVA, Maya ,  ABRAM SALIBA, Johan

    IPC分类号： C07K14/475 ,  A61K38/00 ,  C07K16/22 ,  C07K16/28 ,  C07K14/765 ,  C07K14/47

    CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/70 ,  C12N15/62

    摘要： New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

    摘要翻译： 新设计的对血清白蛋白具有结合特异性的锚蛋白重复结构域，包含至少两个设计的针对血清白蛋白结合特异性的设计的锚蛋白重复结构域的重组结合蛋白，以及包含至少一个设计的具有对肝细胞生长具有结合特异性的设计的锚蛋白重复结构域的重组结合蛋白 描述了至少一个具有对血管内皮生长因子（VEGF-A）具有结合特异性的至少一个设计的锚蛋白重复结构域和至少两个对血清白蛋白具有结合特异性的设计的锚蛋白重复结构域，以及编码这样的核酸 设计的锚蛋白重复结构域和重组结合蛋白，包含这种设计的锚蛋白重复结构域的药物组合物，重组结合蛋白或核酸，以及这些设计的锚蛋白重复结构域，重组结合蛋白，核酸或药物组合物在治疗疾病中的用途。

    RECOMBINANT FAP BINDING PROTEINS AND THEIR USE
    8.
    发明申请
    RECOMBINANT FAP BINDING PROTEINS AND THEIR USE 审中-公开

    公开(公告)号：WO2020245173A1

    公开(公告)日：2020-12-10

    申请号：PCT/EP2020/065317

    申请日：2020-06-03

    申请人： MOLECULAR PARTNERS AG

    发明人： FIEDLER, Ulrike ,  METZ, Clara ,  MÜLLER, Mischa Roland ,  SNELL, Dan

    IPC分类号： A61K38/00

    摘要： The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for fibroblast activation protein (FAR). In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for localizing or delivering a biologically active molecule in FAP-expressing tissue, such as tumor tissue, and for treating, diagnosing or imaging diseases, such as cancer, in a mammal, including a human.