- 专利标题： IDENTIFICATION OF HLA-RESTRICTED PRAME PEPTIDE EPITOPES, PRAME-SPECIFIC T CELLS SUITABLE FOR "OFF-THE-SHELF" TREATMENT OF CANCER EXPRESSING PRAME
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申请号： PCT/US2021/035008申请日： 2021-05-28
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公开(公告)号： WO2021243295A2公开(公告)日： 2021-12-02
- 发明人: BOLLARD, Catherine , HANLEY, Patrick , CRUZ, Conrad Russell Y. , STANOJEVIC, Maja , HONT, Amy
- 申请人： CHILDREN'S NATIONAL MEDICAL CENTER
- 申请人地址： 111 Michigan Avenue, N.W.
- 专利权人： CHILDREN'S NATIONAL MEDICAL CENTER
- 当前专利权人： CHILDREN'S NATIONAL MEDICAL CENTER
- 当前专利权人地址： 111 Michigan Avenue, N.W.
- 代理机构： LOVE, James et al.
- 优先权： US63/031,929 2020-05-29
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C12N5/00 ; A61K2039/5156 ; A61K2039/5158 ; A61K2039/53 ; A61K39/001189
摘要：
The invention pertains to a method for treating a cancer which expresses PRAME using T cells which recognize specific peptide epitopes of PRAME, to a method for producing T cells that target cancer cells expressing PRAME, the peptide epitopes of PRAME themselves and to compositions and methods of treatment using these peptides.
