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发明申请
WO2022007478A1 一种定点突变的载体蛋白及其在制备疫苗中的用途 审中-公开

一种定点突变的载体蛋白及其在制备疫苗中的用途
摘要：
一种定点突变、定点修饰的蛋白抗原及定点突变和定点修饰蛋白抗原的方法，所述方法包括使用基因密码子扩展技术将非天然氨基酸定点引入到蛋白抗原特定位点，借助非天然氨基酸与修饰剂，所述修饰剂如三棕榈酰-S-甘油半胱氨酸、单磷酰脂质A等受体激动剂，与蛋白抗原定点修饰。定点突变、定点修饰的蛋白抗原的应用，如作为疫苗等用途。
摘要（英）：

Provided are a protein antigen subjected to site-directed mutation and site-directed modification, and a method for the site-directed mutation and site-directed modification of the protein antigen. The method comprises: introducing unnatural amino acids into specific sites of the protein antigen in a site-directed way by means of using a gene codon expansion technique; and performing site-directed modification with the protein antigen by means of using the unnatural amino acids and a modifier, wherein the modifier is a receptor agonist such as tripalmitoyl-S-glyceryl cysteine and monophosphoryl lipid A. Further provided is the use of the protein antigen subjected to site-directed mutation and site-directed modification, such as the use of same as a vaccine.

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