Invention Application
- Patent Title: LIVE-ATTENUATED VIRUS VACCINE
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Application No.: PCT/AU2021/050763Application Date: 2021-07-16
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Publication No.: WO2022011428A1Publication Date: 2022-01-20
- Inventor: MAHALINGAM, Surendran , MERITS, Andres , LIU, Xiang
- Applicant: GRIFFITH UNIVERSITY , INDIAN IMMUNOLOGICALS LIMITED
- Applicant Address: 170 Kessels Road; Road No. 44
- Assignee: GRIFFITH UNIVERSITY,INDIAN IMMUNOLOGICALS LIMITED
- Current Assignee: GRIFFITH UNIVERSITY,INDIAN IMMUNOLOGICALS LIMITED
- Current Assignee Address: 170 Kessels Road; Road No. 44
- Agency: SPRUSON & FERGUSON
- Priority: IN202041030397 2020-07-16
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C12N7/00 ; C12N7/04 ; A61K2039/5254 ; A61K39/215 ; A61P31/14 ; C12N2770/20021 ; C12N2770/20034 ; C12N2770/20062
Abstract:
This invention relates to a codon deoptimized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome. In particular, embodiments of the invention concern a vaccine comprising live attenuated SARS-CoV-2 comprising a partly codon deoptimized viral genome, SARS-CoV-2 comprising a partly codon deoptimized viral genome, as well as their use in methods of treatment and prevention of viral infection. The ORF1a region of the viral genome has been codon deoptimized.
Information query
