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公开(公告)号:WO2022236383A1
公开(公告)日:2022-11-17
申请号:PCT/AU2022/050470
申请日:2022-05-16
发明人: JENNINGS, Michael Paul , DAY, Christopher , PATON, Adrienne Webster , PATON, James Cleland , SHEWELL, Lucy
IPC分类号: G01N33/543 , G01N33/574 , C07K14/245
摘要: The present disclosure relates to compositions, kits and methods for preparing and/or analysing biological samples from a subject. These compositions, kits and methods may be useful in applications, such as diagnosing cancer and/or or determining a prognosis therefor.
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公开(公告)号:WO2022192937A1
公开(公告)日:2022-09-22
申请号:PCT/AU2022/050213
申请日:2022-03-14
发明人: JENNINGS, Michael , JEN, Freda (En-Chi) , SEIB, Kate , SEMCHENKO, Evgeny , KIEFEL, Milton , APICELLA, Michael
IPC分类号: A61K39/095 , A61K31/739 , A61K31/702 , C07K16/12 , A61P31/04
摘要: This disclosure relates generally to Neisseria surface moieties. More particularly, the present disclosure relates to oligosaccharides corresponding to Neisseria lipooligosaccharides and to chimeric molecules comprising these moieties for eliciting an immune response to Neisseria organisms and/or for treating or inhibiting the development of Neisseria infections.
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公开(公告)号:WO2022011428A1
公开(公告)日:2022-01-20
申请号:PCT/AU2021/050763
申请日:2021-07-16
IPC分类号: A61K39/12 , C12N7/00 , C12N7/04 , A61K2039/5254 , A61K39/215 , A61P31/14 , C12N2770/20021 , C12N2770/20034 , C12N2770/20062
摘要: This invention relates to a codon deoptimized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome. In particular, embodiments of the invention concern a vaccine comprising live attenuated SARS-CoV-2 comprising a partly codon deoptimized viral genome, SARS-CoV-2 comprising a partly codon deoptimized viral genome, as well as their use in methods of treatment and prevention of viral infection. The ORF1a region of the viral genome has been codon deoptimized.
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公开(公告)号:WO2021222989A1
公开(公告)日:2021-11-11
申请号:PCT/AU2021/050425
申请日:2021-05-07
申请人: GRIFFITH UNIVERSITY
发明人: LU, Junwei , LI, Xiaokun
摘要: A high-frequency rotary transformer, a machine and a high frequency transformer are defined that are simpler to manufacture and less expensive than existing transformers and machines. The high-frequency rotary transformer includes: a primary transformer core comprising a plurality of primary core elements, each defining a primary transformer winding portion; a secondary transformer core comprising a plurality of secondary core elements, each defining a secondary transformer winding portion; a primary winding associated with each of the primary core elements; and a secondary winding associated with each of the secondary core elements. The primary transformer core and the secondary transformer core together define a transformer core having a flux pathway linking the primary and secondary windings, and the primary transformer core and the secondary transformer core are configured to rotate relative to each other. A magnetic flux concentrator may be used to direct magnetic flux towards an inside of the rotary transformer.
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公开(公告)号:WO2021097540A1
公开(公告)日:2021-05-27
申请号:PCT/AU2020/051269
申请日:2020-11-23
申请人: GRIFFITH UNIVERSITY
IPC分类号: A61K39/015 , A61K39/018 , A61K9/127 , A61K47/69 , A61P33/06
摘要: Disclosed are compositions for stimulating a protective or therapeutic immune response to an apicomplexan parasite such as those from the Plasmodium or Babesia genus. More particularly, the compositions comprise a soluble parasite extract. The extract may be free of red blood cell components and/or contained in or associated with a particle such as a liposome. The compositions and methods disclosed herein are particularly useful in the prevention and treatment of parasitic diseases.
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公开(公告)号:WO2020232501A1
公开(公告)日:2020-11-26
申请号:PCT/AU2020/050493
申请日:2020-05-20
申请人: GRIFFITH UNIVERSITY
发明人: BULMER, Andrew , SMITH, Derek , SCOTT, Timothy
IPC分类号: A61M25/02
摘要: A securement device for securement of a catheter connecting assembly to a body of a patient wherein the catheter connecting assembly includes two or more ports adapted to be coupled with the catheter, each port being formed by a respective port body wherein the ports are adapted to be fluidly coupled to a catheter hub of a catheter, the securement device comprising: a base having a continuous top surface and a continuous bottom surface wherein at least a portion of the top surface comprises an antimicrobial layer and wherein at least a portion of the bottom surface comprises an adhesive for attachment of the base to the body of the patient and wherein the base is dimensioned to prevent direct contact between said ports and body of the patient; and one or more retention formations located on the top surface of the base for receiving and retaining at least a portion of a housing comprising said one or more port bodies adapted to be coupled with a terminal end of the catheter.
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公开(公告)号:WO2020124159A1
公开(公告)日:2020-06-25
申请号:PCT/AU2019/051418
申请日:2019-12-20
申请人: GRIFFITH UNIVERSITY
IPC分类号: A61K39/095 , A61P31/04
摘要: This invention relates generally to polynucleotides, polypeptides, compositions, methods and uses for eliciting an immune response to Neisseria , methods for immunizing a subject against a Neisseria infection, and methods for preventing and/or treating a Neisseria infection in a subject. More particularly, the invention relates to antigenic Neisseria polypeptides and encoding polynucleotides, and related uses and methods, including use for preparing compositions and medicaments for eliciting an immune response to Neisseria , for immunizing a subject against a Neisseria infection, and for preventing and/or treating a Neisseria infection in a subject. The invention also relates to methods for producing therapeutic anti- Neisseria antigen-binding molecules, and therapeutic uses of those antigen-binding molecules.
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公开(公告)号:WO2019113645A1
公开(公告)日:2019-06-20
申请号:PCT/AU2018/051337
申请日:2018-12-14
发明人: PARISH, Christopher , O'MEARA, Connor , COUPLAND, Lucy , QUAH, Benjamin Ju Chye , KORDBACHEH, Farzaneh , BEZOS, Anna , BROWNE, Anna , STEPHENS, Ross , TREDWELL, Gregory David , PHILIP, Lee Andrew , KNOX, Karen , VON ITZSTEIN, Laurence Mark , CHANG, Chih-Wei , BRÜSTLE, Anne , DAVIS, David Anak Simon
IPC分类号: A61K31/7028 , A61P7/00 , A61P31/00 , A61P39/00 , A61P43/00
摘要: The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of extracellular histones in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating extracellular histone mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRI)). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of extracellular histone mediated ailments. For example, the present invention relates to methods and uses of β-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS.Na), in the therapy of a range of extracellular histone mediated ailments in subjects.
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公开(公告)号:WO2019000040A1
公开(公告)日:2019-01-03
申请号:PCT/AU2018/050662
申请日:2018-06-28
申请人: GRIFFITH UNIVERSITY
发明人: ZHAO, Huijun
摘要: A sensor for the in situ detection of a target chemical species, comprising a gas permeable membrane having a sampling side and an opposing analytical side, wherein the sampling side of the membrane is capable of receiving a sample and the membrane is permeable to target chemical species present in the sample. A weak acid or a weak base is in contact with the analytical side of the membrane, and a conductivity detector is in contact with the weak acid or weak base. In use, target chemical species present in the sample permeate through the membrane and react with the weak acid or weak base, producing ionic species and changing the conductivity.
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公开(公告)号:WO2018204987A1
公开(公告)日:2018-11-15
申请号:PCT/AU2018/050443
申请日:2018-05-11
申请人: GRIFFITH UNIVERSITY
IPC分类号: C07C311/47 , C07D285/135 , C07D263/44 , A61K31/63 , A61K31/18 , A61K31/433 , A61K31/421 , A61P35/00
CPC分类号: A61K31/433 , A61K31/16 , A61K31/18 , A61K31/421 , A61K31/63 , A61K45/06 , A61P35/00 , C07C311/46 , C07D263/44 , C07D285/135 , C12N9/88 , C12Y402/01001
摘要: Compounds are provided which are inhibitors of the CAXII enzyme. Due to the interaction between CAXII and Pgp, such compounds may be useful in lowering the chemoresistance of a cancer allowing for co-administration with existing anti-cancer agents.
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